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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 6 - 12 (7page)
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Background: Kinetin is a plant hormone that regulates growth and differentiation. Keratinocytes, the basic building blocks of the epidermis, function in maintaining the skin barrier. Objective: We examined whether kinetin induces skin barrier functions in vitro and in vivo. Methods: To evaluate the efficacy of kinetin at the cellular level, expression of keratinocyte differentiation markers was assessed. Moreover, we examined the clinical efficacy of kinetin by evaluating skin moisture, transepidermal water loss (TEWL), and skin surface roughness in patients who used kinetin-containing cream. We performed quantitative real-time polymerase chain reaction to measure the expression of keratinocyte differentiation markers in HaCaT cells following treatment. A clinical trial was performed to assess skin moisture, TEWL, and evenness of skin texture in subjects who used kinetin- containing cream for 4 weeks. Results: Kinetin increased involucrin, and keratin 1 mRNA in HaCaT cells.
Moreover, use of a kinetin-containing cream improved skin moisture and TEWL while decreasing roughness of skin texture. Conclusion: Kinetin induced the expression of keratinocyte differentiation markers, suggesting that it may affect differentiation to improve skin moisture content, TEWL, and other signs of skin aging. Therefore, kinetin is a potential new component for use in cosmetics as an anti-aging agent that improves the barrier function of skin.
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참고문헌 (26)
참고문헌 신청
Amasino R / 2005 / 1955: kinetin arrives: the 50th anniversary of a new plant hormone / Plant Physiol 138 : 1177 ~ 1184
Barciszewski J / 1996 / Evidence for the presence of kinetin in DNA and cell extracts / FEBS Lett 393 : 197 ~ 200
Barciszewski J / 1997 / Furfural, a precursor of the cytokinin hormone kinetin, and base propenals are formed by hydroxyl radical damage of DNA / Biochem Biophys Res Commun
Barciszewski J / 2000 / Identification of 6-furfuryladenine (kinetin) in human urine / Biochem Biophys Res Commun 279 : 69 ~ 73
Berge U / 2006 / Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro / Ann N Y Acad Sci 1067 : 332 ~ 336
Barciszewski J / 1996 / Evidence for the presence of kinetin in DNA and cell extracts / FEBS Lett 393 : 197 ~ 200
Barciszewski J / 1997 / Furfural, a precursor of the cytokinin hormone kinetin, and base propenals are formed by hydroxyl radical damage of DNA / Biochem Biophys Res Commun
Barciszewski J / 2000 / Identification of 6-furfuryladenine (kinetin) in human urine / Biochem Biophys Res Commun 279 : 69 ~ 73
Berge U / 2006 / Kinetin-induced differentiation of normal human keratinocytes undergoing aging in vitro / Ann N Y Acad Sci 1067 : 332 ~ 336
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