지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 265 - 275 (11page)
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초록· 키워드
오류제보하기
Epidermal barrier formation and the maintenance of barrier homeostasis are essential to protect us from the external environments and organisms. Moreover, impaired keratinocytes differentiation and dysfunctional skin barrier can be the primary causes or aggravating factors for many inflammatory skin diseases including atopic dermatitis and psoriasis. Therefore, understanding the regulation mechanisms of keratinocytes differentiation and skin barrier homeostasis is important to understand many skin diseases and establish an effective treatment strategy. Calcium ions (Ca2＋) and their concentration gradient in the epidermis are essential in regulating many skin functions, including keratinocyte differentiation, skin barrier formation, and permeability barrier homeostasis. Recent studies have suggested that the intracellular Ca2＋ stores such as the endoplasmic reticulum (ER) are the major components that form the epidermal calcium gradient and the ER calcium homeostasis is crucial for regulating keratinocytes differentiation, intercellular junction formation, antimicrobial barrier, and permeability barrier homeostasis. Thus, both Ca2＋ release from intracellular stores, such as the ER and Ca2＋ influx mechanisms are important in skin barrier. In addition, growing evidences identified the functional existence and the role of many types of calcium channels which mediate calcium flux in keratinocytes. In this review, the origin of epidermal calcium gradient and their role in the formation and regulation of skin barrier are focused. We also focus on the role of ER calcium homeostasis in skin barrier. Furthermore, the distribution and role of epidermal calcium channels, including transient receptor potential channels, store-operated calcium entry channel Orai1, and voltage-gated calcium channels in skin barrier are discussed.
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참고문헌 (99)
참고문헌 신청
Menon GK / 1985 / Ionic calcium reservoirs in mammalian epidermis: ultrastructural localization by ion-capture cytochemistry / J Invest Dermatol 84:508~512
Menon GK / 1991 / Ultrastructural localization of calcium in psoriatic and normal human epidermis / Arch Dermatol 127:57~63
Elias P / 2002 / Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms / J Invest Dermatol 119:1269~1274
Lee SH / 1992 / Calcium and potassium are important regulators of barrier homeostasis in murine epidermis / J Clin Invest 89:530~538
Lee SH / 1994 / A role for ions in barrier recovery after acute perturbation / J Invest Dermatol 102:976~979
Menon GK / 1991 / Ultrastructural localization of calcium in psoriatic and normal human epidermis / Arch Dermatol 127:57~63
Elias P / 2002 / Origin of the epidermal calcium gradient: regulation by barrier status and role of active vs passive mechanisms / J Invest Dermatol 119:1269~1274
Lee SH / 1992 / Calcium and potassium are important regulators of barrier homeostasis in murine epidermis / J Clin Invest 89:530~538
Lee SH / 1994 / A role for ions in barrier recovery after acute perturbation / J Invest Dermatol 102:976~979
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