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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 699 - 705 (7page)
이용수
초록· 키워드
오류제보하기
Background: Onychomycosis is one of the most prevalent fungal diseases in the general population. However, treatment is of limited effectiveness and must be administered for long periods of time. Systemic antifungal agents are associated with adverse effects. Objective: We evaluated the clinical efficacy and safety of a 1,064-nm neodymium-doped yttrium aluminium garnet (Nd:YAG) laser with amorolfine nail lacquer to treat onychomycosis. Methods: The 128 patients were randomly divided to 2 groups: 64 in the experimental group were treated with 1,064-nm Nd:YAG laser therapy and amorolfine nail lacquer; the other 64 were in a control group treated with topical amorolfine lacquer monotherapy. The laser treatment was 4 sessions at 4-week intervals and amorolfine lacquer was applied once a week for 16 weeks. Efficacy was assessed as response rate from standardized photographs with ImageProⓇPlus (Media Cybernetics, Inc., USA) analysis, microscopic examination, and subjective evaluation. Results: At 16 weeks, the experimental group showed a significantly higher cumulative cure rate than the control group (71.88% vs. 20.31%, p ＜0.0001). Clinical therapeutic effects were linked to patient satisfaction. The percent of "very satisfied" or "satisfied" responses was higher in the test group than the control group (81.25% vs. 23.44%). The treatment regimen was well tolerated, with transient discomfort observed in the test group.
Conclusion: The 1,064-nm Nd:YAG laser with amorolfine nail lacquer was effective and safe for treating onychomycosis.
This therapy should be considered an alternative treatment, especially for patients with contraindications to systemic antifungal agents.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Borgers M / 1980 / Mechanism of action of antifungal drugs, with special reference to the imidazole derivatives / Rev Infect Dis 2 : 520 ~ 534
Carney C / 2013 / Treatment of onychomycosis using a submillisecond 1064-nm neodymium:yttrium-aluminum-garnet laser / J Am Acad Dermatol 69 : 578 ~ 582
El-Tatawy RA / 2015 / A comparative clinical and mycological study of Nd-YAG laser versus topical terbinafine in the treatment of onychomycosis / J Dermatolog Treat 26 : 461
Gupta AK / 2000 / Prevalence and epidemiology of onychomycosis in patients visiting physicians' offices: a multicenter canadian survey of 15,000 patients / J Am Acad Dermatol
Gupta AK / 2004 / Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis / Br J Dermatol 150 : 537 ~ 544
Carney C / 2013 / Treatment of onychomycosis using a submillisecond 1064-nm neodymium:yttrium-aluminum-garnet laser / J Am Acad Dermatol 69 : 578 ~ 582
El-Tatawy RA / 2015 / A comparative clinical and mycological study of Nd-YAG laser versus topical terbinafine in the treatment of onychomycosis / J Dermatolog Treat 26 : 461
Gupta AK / 2000 / Prevalence and epidemiology of onychomycosis in patients visiting physicians' offices: a multicenter canadian survey of 15,000 patients / J Am Acad Dermatol
Gupta AK / 2004 / Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis / Br J Dermatol 150 : 537 ~ 544
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