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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2009.1
- 수록면
- 376 - 381 (6page)
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Background: Nkx2.5 is a homeodomain-containing nuclear transcription protein that has been associated with acute T-lymphoblastic leukemia. In addition, Nkx2.5 has an essential role in cardiomyogenesis. However, the expression of Nkx2.5 in the skin has not been investigated. Objective: In an attempt to screen the differentially regulated genes involved in keratinocyte differentiation, using a cDNA microarray, we identified Nkx2.5 as one of the transcription factors controlling the expression of proteins associated with keratinocyte differentiation. Methods: To investigate the expression of Nkx2.5 during keratinocyte differentiation, we used a calcium-induced keratinocyte differentiation model.
Results: RT-PCR and Western blot analysis revealed that the expression of Nkx2.5, in cultured human epidermal keratinocytes, increased with calcium treatment in a time-dependent manner. In normal skin tissue, the expression of Nkx2.5 was detected in the nuclei of the keratinocytes in all layers of the epidermis except the basal layer by immunohistochemistry.
In addition, the expression of Nkx2.5 was significantly increased in psoriasis and squamous cell carcinoma, but was barely detected in atopic dermatitis and basal cell carcinoma. Conclusion: These results suggest that Nkx2.5 may play a role in the change from proliferation to differentiation of keratinocytes and in the pathogenesis of skin disease with aberrant keratinocyte differentiation.
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참고문헌 (20)
참고문헌 신청
Akazawa H / 2005 / Cardiac transcription factor Csx/Nkx2-5: Its role in cardiac development and diseases / Pharmacol Ther 107 : 252 ~ 268
Fuchs E / 1993 / Epidermal differentiation and keratin gene expression / J Cell Sci Suppl 17 : 197 ~ 208
Han C / 2006 / Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis / J Rheumatol 33 : 2167 ~ 2172
Harvey RP / 1996 / NK-2 Homeobox genes and heart development / Dev Biol 178 : 203 ~ 216
Kalinin AE / 2002 / Epithelial barrier function: assembly and structural features of the cornified cell envelope / Bioessays 24 : 789 ~ 800
Fuchs E / 1993 / Epidermal differentiation and keratin gene expression / J Cell Sci Suppl 17 : 197 ~ 208
Han C / 2006 / Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis / J Rheumatol 33 : 2167 ~ 2172
Harvey RP / 1996 / NK-2 Homeobox genes and heart development / Dev Biol 178 : 203 ~ 216
Kalinin AE / 2002 / Epithelial barrier function: assembly and structural features of the cornified cell envelope / Bioessays 24 : 789 ~ 800
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