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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 579 - 585 (7page)
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Background: Interleukin-17A (IL-17A) is mainly secreted from Th17 cells that are activated by various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand. Recently, it has been demonstrated that keratinocytes play an important role in the pathogenesis of psoriasis.
Objective: To investigate the potential role of keratinocytes, we examined whether TLR9 ligand CpG induces IL-17A expression in keratinocytes. Methods: We used HaCaT keratinocytes as a model system, and determined CpG-induced IL-17A using enzyme-linked immunosorbent assay and Western blot. Results: When HaCaT keratinocytes were treated with CpG, the expression of several cytokines including IL-17A, tumor necrosis factor-α and CCL20 was markedly increased. Treatment with nuclear factor (NF)-κB inhibitor significantly blocked the CpG-induced IL-17A production, indicating that CpG induced IL-17A expression through the NF-κB signaling pathway. In addition, IL-17A secreted from keratinocytes stimulated the CD4+ T cells, resulting in strong induction of IL-22 production. Conclusion: Since IL-22 is an important mediator for psoriatic inflammation, our data suggest that keratinocytes can participate in the pathogenesis of psoriasis via the TLR9-dependent IL-17A production.
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참고문헌 (32)
참고문헌 신청
Li Y. / 2009 / Unraveling the genetics of complex diseases : susceptibility genes for rheumatoid arthritis and psoriasis / Semin Immunol 21:318~327
Nakajima H. / 2011 / Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients / Arch Dermatol Res 303:451~455
Becher B. / 2012 / Hiding under the skin : interleukin-17-producing γδ T cells go under the skin? / Nat Med 18:1748~1750
Pappu R. / 2012 / Regulation of epithelial immunity by IL-17 family cytokines / Trends Immunol 33:343~349
Iwakura Y. / 2008 / The roles of IL-17A in inflammatory immune responses and host defense against pathogens / Immunol Rev 226:57~79
Nakajima H. / 2011 / Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients / Arch Dermatol Res 303:451~455
Becher B. / 2012 / Hiding under the skin : interleukin-17-producing γδ T cells go under the skin? / Nat Med 18:1748~1750
Pappu R. / 2012 / Regulation of epithelial immunity by IL-17 family cytokines / Trends Immunol 33:343~349
Iwakura Y. / 2008 / The roles of IL-17A in inflammatory immune responses and host defense against pathogens / Immunol Rev 226:57~79
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