지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 715 - 720 (6page)
이용수
초록· 키워드
오류제보하기
Background: The necessity of performing antifungal susceptibility tests is recently increasing because of frequent cases of oral candidiasis caused by antifungal-resistant Candida species. The Etest (BioMerieux, Marcy l'Etoile, France) is a rapid and easy-to-perform in vitro antifungal susceptibility test. Objective: The purpose of this study was to determine the minimal inhibitory concentrations (MICs) of antifungal agents by using the Etest for Candida species isolated from patients with oral candidiasis. Methods: Forty-seven clinical isolates of Candida species (39 isolates of Candida albicans, 5 isolates of C. glabrata, and 3 isolates of C. tropicalis) were tested along with a reference strain (C. albicans ATCC 90028). The MIC end points of the Etest for fluconazole, itraconazole, voriconazole, and amphotericin B susceptibility were read after the 24-hour incubation of each isolate on RPMI 1640 agar. Results: All Candida isolates were found susceptible to voriconazole and amphotericin B. However, all five isolates of C. glabrata were resistant to itraconazole, among which two isolates were also resistant to fluconazole.
Conclusion: This study revealed that the Etest represented a simple and efficacious method for antifungal susceptibility testing of Candida species isolated from oral candidiasis patients. Therefore, voriconazole and amphotericin B should be recommended as effective alternatives for the treatment of oral candidiasis.
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참고문헌 (22)
참고문헌 신청
Ahn HH / 2014 / Textbook of dermatology / Daehan Medical Books : 430 ~ 437
Arikan S / 2007 / Current status of antifungal susceptibility testing methods / Med Mycol 45 : 569 ~ 587
Bagg J / 2005 / Voriconazole susceptibility of yeasts isolated from the mouths of patients with advanced cancer / J Med Microbiol 54 : 959 ~ 964
Belazi M / 2004 / Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer:prevalence, azole susceptibility profiles and response to antifungal tre
Carvalhinho S / 2012 / Susceptibilities of Candida albicans mouth isolates to antifungal agents, essentials oils and mouth rinses / Mycopathologia 174 : 69 ~ 76
Arikan S / 2007 / Current status of antifungal susceptibility testing methods / Med Mycol 45 : 569 ~ 587
Bagg J / 2005 / Voriconazole susceptibility of yeasts isolated from the mouths of patients with advanced cancer / J Med Microbiol 54 : 959 ~ 964
Belazi M / 2004 / Oral Candida isolates in patients undergoing radiotherapy for head and neck cancer:prevalence, azole susceptibility profiles and response to antifungal tre
Carvalhinho S / 2012 / Susceptibilities of Candida albicans mouth isolates to antifungal agents, essentials oils and mouth rinses / Mycopathologia 174 : 69 ~ 76
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