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논문 기본 정보

자료유형
학술저널
저자정보
Jeon Suhak (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U) Shin Jong Hee (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U) Lim Ha Jin (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U) Choi Min Ji (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U) Byun Seung A (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U) Lee Dain (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U) Lee Seung Yeob (Department of Laboratory Medicine Jeonbuk National University Medical School and Jeonbuk National U) Won Eun Jeong (Department of Parasitology and Tropical Medicine Chonnam National University Medical School Hwasun) Kim Soo Hyun (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U) Shin Myung Geun (Department of Laboratory Medicine Chonnam National University Medical School and Chonnam National U)
저널정보
대한진단검사의학회 Annals of Laboratory Medicine Annals of Laboratory Medicine 제41권 제6호
발행연도
2021.11
수록면
559 - 567 (9page)
DOI
10.3343/alm.2021.41.6.559

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Background: Given the increased fluconazole resistance (FR) among Candida isolates, we assessed the suitability of disk diffusion susceptibility testing (DDT) for the early detection of FR using well-characterized Candida isolates. Methods: In total, 188 Candida isolates, including 66 C. albicans (seven Erg11 mutants), 69 C. glabrata (33 Pdr1 mutants), 29 C. parapsilosis (15 Erg11 mutants), and 24 C. tropicalis (eight Erg11 mutants) isolates, were tested in this study. FR was assessed using DDT according to the standard CLSI M44-ED3 method, except that two cell suspensions, McFarland 0.5 (standard inoculum) and 2.5 (large inoculum), were used, and the inhibition zones were read at 2-hour intervals from 10 hours to 24 hours. Results: DDT results for the standard inoculum were readable after 14 hours (C. albicans, C. glabrata, and C. tropicalis) and 20 hours (C. parapsilosis) for >95% of the isolates, whereas the results for the large inoculum were readable after 12 hours (C. glabrata and C. tropicalis), 14 hours (C. albicans), and 16 hours (C. parapsilosis) for >95% of the isolates. Compared with the results produced using the CLSI M27-ED4 broth microdilution method, the first readable results from the DDT method for each isolate exhibited an agreement of 97.0%, 98.6%, 72.4%, and 91.7% for the standard inoculum and 100%, 98.6%, 96.6%, and 95.8% for the large inoculum for C. albicans, C. glabrata, C. parapsilosis, and C. tropicalis, respectively. Conclusions: DDT using large inoculum may detect FR rapidly and reliably in the four most common Candida species.
#Candida #Fluconazole #Resistance #Disk diffusion #CLSI #Antifungal susceptibility testing

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참고문헌 (26)

참고문헌 신청
Kullberg BJ / 2015 / Invasive candidiasis / N Engl J Med 373:1445~1456 google schola Ha Jin Lim / 2020 / First Case of Nosocomial Fungemia Caused by Candida melibiosica / Annals of Laboratory Medicine 40(2):177~179 Crossref Pfaller MA / 2016 / Twenty years of the SENTRY antifungal surveillance program: results for Candida species from 1997–2016 / Open Forum Infect Dis 6(S1):S79~S94 google schola Arendrup MC / 2017 / Multidrug-resistant Candida: epidemiology, molecular mechanisms, and treatment / J Infect Dis 216(S3):S445~S451 google schola Pappas PG / 2016 / Clinical practice guideline for the management of candidiasis: 2016 update by the Infectious Diseases Society of America / Clin Infect Dis 62:e1~e50 google schola

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