지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Osteoporosis is a systemic skeletal disease whose risk increases with age and it is common among postmenopausal women. Currently, almost all pharmacological agents for osteoporosis target the bone resorption component of bone remodeling activity. Current antiresorptive agents are effective, but the effectiveness of some agents is limited by real or perceived intolerance, longterm adverse events (AEs), coexisting comorbidities, and inadequate long-term adherence. New antiresorptive therapies that may expand options for the prevention and treatment of osteoporosis include denosumab, combination of conjugated estrogen/bazedoxifene and cathepsin K inhibitors. However, the long-term efficacy and AEs of these antiresorptive therapies need to be confirmed in studies with a longer follow-up period. (J Menopausal Med 2015;21:1-11)
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Amgen Inc. / / Prolia® (denosumab)
Bekker PJ. / 2004 / A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women / J Bone Miner Res 19 : 1059 ~ 1066
Block GA. / 2012 / A singledose study of denosumab in patients with various degrees of renal impairment / J Bone Miner Res 27 : 1471 ~ 1479
Bone HG. / 2011 / Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass / J Clin En
Boonen S. / 2011 / Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk / J Clin Endocrinol Metab 96 : 1727
Bekker PJ. / 2004 / A single-dose placebo-controlled study of AMG 162, a fully human monoclonal antibody to RANKL, in postmenopausal women / J Bone Miner Res 19 : 1059 ~ 1066
Block GA. / 2012 / A singledose study of denosumab in patients with various degrees of renal impairment / J Bone Miner Res 27 : 1471 ~ 1479
Bone HG. / 2011 / Effects of denosumab treatment and discontinuation on bone mineral density and bone turnover markers in postmenopausal women with low bone mass / J Clin En
Boonen S. / 2011 / Treatment with denosumab reduces the incidence of new vertebral and hip fractures in postmenopausal women at high risk / J Clin Endocrinol Metab 96 : 1727
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