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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 108 - 111 (4page)
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denosumab treatment in Japanese women with primary osteoporosis or rheumatoid arthritis (RA) with osteoporosis. Methods: This retrospective study included 143 patients with primary osteoporosis and 96 patients with RA and osteoporosis who were treated with denosumab. Treatment discontinuation, fracture occurrence, lumbar spine (L1e4) bone mineral density (LS-BMD), and bilateral total hip BMD (TH-BMD) were examined before and at 1 and 2 years after treatment commencement. Results: In the primary osteoporosis group, 32 cases dropped out and no fractures occurred from 0 to 1 year. Eighteen cases were lost to follow-up and no fractures were noted from 1 to 2 years. In the RA with osteoporosis group, 7 cases dropped out and no fracture occurred from 0 to 1 year. Twenty-one cases were lost to follow-up and 2 nonvertebral fractures were noted from 1 to 2 years. In this group, 13 cases dropped out from 1 to 2 years and 16 cases dropped out during the 2-year study period due to economic reasons. LS-BMD and TH-BMD values increased continuously for 2 years of treatment in both primary osteoporosis and RA with osteoporosis groups. Conclusions: These results suggest that during denosumab therapy, the discontinuation rate is expected to remain low during 2 years of treatment in primary osteoporotic patients. In RA patients with osteoporosis, however, the discontinuation rate may increase due to economic reasons from 1 to 2 years of therapy.
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참고문헌 (10)
참고문헌 신청
Blouin J / 2007 / Discontinuation of antiresorptive therapies: a comparison between 1998-2001 and 2002-2004among osteoporotic women / J Clin Endocrinol Metab 92:887~894
Hadji P / 2016 / GRAND-4: the German retrospective analysis of long-term persistence in women with osteoporosis treated with bisphosphonates or denosumab / Osteoporos Int 27:2967~2978
Watt J / 2014 / There is still a care gap in osteoporosis management for patients with rheumatoid arthritis / Jt Bone Spine 81:347~351
Nakamura Y / 2015 / Changes in serum vitamin D and PTH values using denosumab with or without bisphosphonate pre-treatment in osteoporotic patients: a short-term study / BMC Endocr Disord 15:81
Leder BZ / 2015 / Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATASwitch study): extension of a randomised controlled trial / Lancet 386:1147~1155
Hadji P / 2016 / GRAND-4: the German retrospective analysis of long-term persistence in women with osteoporosis treated with bisphosphonates or denosumab / Osteoporos Int 27:2967~2978
Watt J / 2014 / There is still a care gap in osteoporosis management for patients with rheumatoid arthritis / Jt Bone Spine 81:347~351
Nakamura Y / 2015 / Changes in serum vitamin D and PTH values using denosumab with or without bisphosphonate pre-treatment in osteoporotic patients: a short-term study / BMC Endocr Disord 15:81
Leder BZ / 2015 / Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATASwitch study): extension of a randomised controlled trial / Lancet 386:1147~1155
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