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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Endogenous nitric oxide (NO) has been known to regulate many physiological and pathological processes, especially
the glandular secretion and blood flow. However, nitric oxide synthase (NOS) responsible for NO synthesis has not been
well studied ultrastructurally in rat salivary gland. The present study was performed to investigate the distribution of
nitric oxide synthase isoforms (endothelial, neuronal, and inducible NOS). Immunoelectron microscopic study, using monoclonal
mouse anti-endothelial NOS, anti-neuronal NOS, and anti-inducible NOS, was performed in the salivary gland
of rat.
Endothelial NOS (eNOS)-positive immunoreactivities were most prominent in the secretory granules of serous cells of
the salivary gland of the rat. Immunoreactivities were well concentrated on serous secretory granules in the serous cells.
However, weak eNOS-positive immunoreactivity was observed in the mucous secretory granules of the mucous cells.
Positive endothelial NOS (eNOS) immunoreactivities were most prominent in the secretory granules of intralobular ducts.
Ductal secretory granules and acinar serous secretory granules have a similar pattern of labeling as eNOS suggestings.
Neural NOS (nNOS)-positive immunoreactivity was not detected in duct systems or in acinar cells. Inducible NOS
(iNOS)-positive immunoreactivity was not seen in acinar and ductal cells.
These results reveal the presence of eNOS in the salivary gland of the rat, which may be related with regulation of the
glandular secretion and blood flow through the gland.
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참고문헌 (22)
참고문헌 신청
Ahn KY / 1994 / In situ hybridization localization of mRNA encoding inducible nitric oxide synthase in rat kidney / Am J Physiol 267 : F748 ~ F757
Alm P / 1995 / Nitric oxide synthase-containing neurons in rat parasympathetic, sympathetic and sendory ganglia: a xomparative study / Histochem J 27 : 819 ~ 831
Arzumanian V / 2003 / Mechanism of nitric oxide synthesis and action in cells / Medicina 39 : 535 ~ 541
Beauregard C / 2003 / Induction of nitric oxide synthase and over-production of nitric oxide by interleukin-1β in cultured lacrimal gland acinar cells / Exp Eye Res 77 : 109
Brennan PA / 2003 / The role of nitric oxide in oral diseases / Arch Oral Biol 48 : 93 ~ 100
Alm P / 1995 / Nitric oxide synthase-containing neurons in rat parasympathetic, sympathetic and sendory ganglia: a xomparative study / Histochem J 27 : 819 ~ 831
Arzumanian V / 2003 / Mechanism of nitric oxide synthesis and action in cells / Medicina 39 : 535 ~ 541
Beauregard C / 2003 / Induction of nitric oxide synthase and over-production of nitric oxide by interleukin-1β in cultured lacrimal gland acinar cells / Exp Eye Res 77 : 109
Brennan PA / 2003 / The role of nitric oxide in oral diseases / Arch Oral Biol 48 : 93 ~ 100
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