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Liver regeneration is a result of highly coordinated proliferation of hepatocytes and non-parenchymal liver cells. At
this process, induction of metallothionein (MT), which is low molecular and cysteine rich, has been reported. The present
study was carried to find the ultrastructure of hepatocytes and determine the expression of MT in regenerating rat liver
after partial hepatectomy. As a result, the remnant liver after PH grew fast from 1 day until 7 days. Various changes were
morphologically observed. Disintegration of cell plates and liver lobule appeared shortly after PH. And hepatocytes
showed the rapid proliferation, characterized by high nuclear cytoplasmic ratio, weak intercellular junctional complexes,
chromatin condensation, increase of ribosomes and mitochondria, and temporary increase of lipid droplets. Finally, remodeling
of the liver lobule was completed through the rearrangement of blood vessels and cell plates by 7 days after PH. On
histochemistry, immunoreactivity indicating the presence of MT appeared moderately throughout the cytoplasm of control
rat hepatocyte. After PH, positive reactions for MT increased at the cytoplasm and the nucleus. These results suggest
that the remnant liver cells immediately entered cell proliferation and increase of MT expression after PH. It is thought
that MT protein might be associated with transfer of some factors needed to cell division from the cytoplasm to the nucleus
for regeneration of the liver after PH.
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참고문헌 (19)
참고문헌 신청
Ahn YM / 2005 / Immunogold labellings and expression of metallothionein in regenerating rat liver / Korean J Electron Microscopy 35 : 15 ~ 22
Banerjee D / 1982 / Immuno-histochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney / Toxicology 24 : 95 ~ 105
Carnovale CE / 2000 / Nitric oxide release and enhancement of lipid in regenerating rat liver peroxidation / J Hepatol 32 : 798 ~ 804
Cheeseman KH / 1988 / Studies on lipid peroxidation in normal and tumor tissue / Biochem J 250 : 247 ~ 252
Clough SR / 1986 / Qualitative and quantitative aspects of human fetal liver metallothioneins / Biol Neonate 49 : 241 ~ 254
Banerjee D / 1982 / Immuno-histochemical localization of metallothionein in cell nucleus and cytoplasm of rat liver and kidney / Toxicology 24 : 95 ~ 105
Carnovale CE / 2000 / Nitric oxide release and enhancement of lipid in regenerating rat liver peroxidation / J Hepatol 32 : 798 ~ 804
Cheeseman KH / 1988 / Studies on lipid peroxidation in normal and tumor tissue / Biochem J 250 : 247 ~ 252
Clough SR / 1986 / Qualitative and quantitative aspects of human fetal liver metallothioneins / Biol Neonate 49 : 241 ~ 254
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