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초록· 키워드
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The effects of postnatal exposure to octylphenol (OP) on the expressions of
the steroidogenic enzymes and testosterone production were evaluated. Postnatal
male mice (15-day-old) were injected with 2 or 20 mg kg-1 body weight (BW) of OP for 5
days and sacrificed on postnatal day 21. Testosterone concentration was measured by
radioimmunoassay and the expressions of the testicular genes were determined by
RT-PCR analyses. Significant reductions in the mean body and testis weight were
observed in the OP treated animals. No marked alteration in the histological structure
of the testis were observed, however, slight reduction in the seminiferous tubule
diameter and the number of Leydig cells and several pyknotic cells could be identified
in the 20 mg kg-1 BW of the OP treated animals. Serum testosterone concentration was
dramatically reduced and the mRNA expressions of the steroidogenic acute regulatory
protein (StAR), cholesterol side-chain cleavage enzyme (P450scc) and 17β-hydroxylase/
C17-20 lyase (P45017α) were decreased. No significant changes of the gene expressions
of the steroidogenic factor-1 (SF-1) and estrogen and androgen receptor after
the OP treatment showed that the decreased expressions of the steroidogenic enzymes
in the present study did not correlate with these genes. Altogether, the present study
demonstrates that postnatal treatment of OP inhibits steroidogenesis by decreasing
the transcriptional expressions of the StAR and steroidogenic enzymes. The alteration
in steroidogenesis may adversely affect the normal development of the testis and spermatogenesis.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Blake CA / 1997 / Chronic administrationof the environmental pollutant 4-tert-octylphenol toadult male rats interferes with the secretion of luteinizinghormone, follicle-stim
Boockfor FR / 1997 / Chronic administrationof 4-tert-octylphenol to adult male rats causes shrinkageof the testes and male accessory sec organs, disruptsspermatogenesis, and
Guillette LJ Jr / 2001 / Alterations indevelopment of reproductive and endocrine systems ofwildlife populations exposed to endocrine-disruptingcontaminants 122 : 857 ~ 864
Gupta C / 1999 / Modulation of androgen receptor (AR)-mediated transcriptional activity by EGF in the developingmouse reproductive tract primary cells 152 : 169 ~ 178
Haavisto TE / 2003 / Effects of 4-tert-octylphenol, 4-tertbutylphenol,and diethylstilbesterol on prenatal testosteronesurge in the rat 17 : 593 ~ 605
Boockfor FR / 1997 / Chronic administrationof 4-tert-octylphenol to adult male rats causes shrinkageof the testes and male accessory sec organs, disruptsspermatogenesis, and
Guillette LJ Jr / 2001 / Alterations indevelopment of reproductive and endocrine systems ofwildlife populations exposed to endocrine-disruptingcontaminants 122 : 857 ~ 864
Gupta C / 1999 / Modulation of androgen receptor (AR)-mediated transcriptional activity by EGF in the developingmouse reproductive tract primary cells 152 : 169 ~ 178
Haavisto TE / 2003 / Effects of 4-tert-octylphenol, 4-tertbutylphenol,and diethylstilbesterol on prenatal testosteronesurge in the rat 17 : 593 ~ 605
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