지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
이용수
초록· 키워드
오류제보하기
Background: Despite the increase of infections caused by dematiaceous fungi, the antifungal
susceptibility of these fungi has been the little study. It is necessary to perform antifungal susceptibility
testing of dematiaceous fungi. Etest (AB Biodisk, Sweden) is a rapid, easy-to-perform in-vitro antifungal
susceptibility test.
Objective: The purpose of the study was to investigate the minimal inhibitory concentration (MICs)
of dematiaous fungi isolated from skin lesion using Etest.
Methods: The dematiaceous fungal strains studied were nine clinical isolates of chromoblastomycosis
and phaeohyphomycosis agents (3 strains of Exophiala dermatitidis, 4 strains of Fonsecaea pedrosoi, 2
strains of Exophiala jeanselmei) and two standard strains (Aspergillus flavus KCTC 6905, Aspergillus
fumigatus KCTC 6145). MIC endpoints of Etest for amphotericin B (AMB) and itraconazole (ITZ)
susceptibility were read after 72, 96, and 120 hours incubation for each isolates on RPMI 1640 agar.
Results: MIC of AMB was 0.125~1.0 μg/mL on E. dermatitidis & F. pedrosoi, and 0.19~0.25 μg/
mL on E. jeanselmei. MIC of ITZ was 0.38~1.5 μg/mL on E. dermatitidis, 0.016~0.125 μg/mL on F.
pedrosoi, and 0.064~0.25 μg/mL on E. jeanselmei. Two strains of E. dermatitidis isolated from Korean
patients with phaeohyphomycosis showed ITZ-resistant.
Conclusion: This study showed that Etest represented a simple and efficacious method for antifungal
susceptibility testing of dematiaceous fungi.
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
Andrade TS / 2004 / Susceptibility of sequential Fonsecaea pedrosoi isolates from chromoblastomycosis patients to antifungal agents / Mycoses 47 : 216 ~ 221
Arikan S. / 2007 / Current status of antifu
Caligiorne RB / 1999 / In vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs / Med Mycol 37 : 405 ~ 409
Clancy CJ / 2000 / Subcutaneous phaeohyphomycosis in transplant recipients: review of the literature and demonstration of in vitro synergy between antifungal agents / Med My
De Hoog GS / 2000 / Atlas of clinical fungi. 2nd ed / Centraalbureau voor Schimmelcultures : 652 ~ 657
Arikan S. / 2007 / Current status of antifu
Caligiorne RB / 1999 / In vitro susceptibility of chromoblastomycosis and phaeohyphomycosis agents to antifungal drugs / Med Mycol 37 : 405 ~ 409
Clancy CJ / 2000 / Subcutaneous phaeohyphomycosis in transplant recipients: review of the literature and demonstration of in vitro synergy between antifungal agents / Med My
De Hoog GS / 2000 / Atlas of clinical fungi. 2nd ed / Centraalbureau voor Schimmelcultures : 652 ~ 657
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