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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 148 - 156 (9page)
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초록· 키워드
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Esophagogastric junction (EGJ) cancer is a solid tumor entity with rapidly increasing incidence in the Western countries. Given the high proportion of advanced cancers in the West, treatment strategies routinely employed include surgery and chemotherapy perioperatively, and chemoradiation in neoadjuvant settings. Neoadjuvant chemoradiation and perioperative chemotherapy are mostly performed in esophageal cancer that extends to the EGJ and gastric as well as EGJ cancers, respectively. Recent trials have tried to combine both strategies in a perioperative context, which might have beneficial outcomes, especially in patients with EGJ cancer. However, it is difficult to recruit patients for trials, exclusively for EGJ cancers; therefore, the results have to be carefully reviewed before establishing a standard protocol. Trastuzumab was the first drug for targeted therapy that was positively evaluated for this tumor entity, and there are several ongoing trials investigating more targeted drugs in order to customize effective therapies based on tissue characteristics. The current study reviews the multimodal treatment concept for EGJ cancers in the West and summarizes the latest reports.
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참고문헌 (25)
참고문헌 신청
Fitzmaurice C / 2015 / The Global Burden of Cancer 2013 / JAMA Oncol 1:505~527
Buas MF / 2013 / Epidemiology and risk factors for gastroesophageal junction tumors: understanding the rising incidence of this disease / Semin Radiat Oncol 23:3~9
Sasako M / 2011 / Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer / J Clin Oncol 29:4387~4393
Sakuramoto S / 2007 / Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine / N Engl J Med 357:1810~1820
Bang YJ / 2012 / Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial / Lancet 379:315~321
Buas MF / 2013 / Epidemiology and risk factors for gastroesophageal junction tumors: understanding the rising incidence of this disease / Semin Radiat Oncol 23:3~9
Sasako M / 2011 / Five-year outcomes of a randomized phase III trial comparing adjuvant chemotherapy with S-1 versus surgery alone in stage II or III gastric cancer / J Clin Oncol 29:4387~4393
Sakuramoto S / 2007 / Adjuvant chemotherapy for gastric cancer with S-1, an oral fluoropyrimidine / N Engl J Med 357:1810~1820
Bang YJ / 2012 / Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial / Lancet 379:315~321
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