Acotiamide Has No Effects on Esophageal Motor Activity or Esophagogastric Junction Compliance

Hironobu Mikami; Norihisa Ishimura; Mayumi Okada; Daisuke Izumi; Eiko Okimoto; Shunji Ishihara; Yoshikazu Kinoshita

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자료유형: 학술저널

저자정보: Hironobu Mikami (Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo Japan) Norihisa Ishimura (Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo Japan) Mayumi Okada (Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo Japan) Daisuke Izumi (Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo Japan) Eiko Okimoto (Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo Japan) Shunji Ishihara (Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo Japan) Yoshikazu Kinoshita (Second Department of Internal Medicine Shimane University Faculty of Medicine Izumo Japan)

저널정보: 대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.24 No.2

발행연도: 2018.1

수록면: 241 - 247 (7page)

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Background/Aims The novel prokinetic drug acotiamide is used for treatment of functional dyspepsia. It is still unclear how acotiamide has effects on esophageal motor function. Esophageal peristalsis and esophagogastric junction (EGJ) compliance has an important role for prevention of esophageal mucosal damage caused by gastroesophageal reflux, however, few studies have analyzed the effects of acotiamide on those former activities and none have investigated its effects on EGJ compliance. The aim of our research was to examine the effects of acotiamide on esophageal motility and EGJ compliance. Methods We enrolled 3 gastroesophageal reflux disease (GERD) patients as well as 9 healthy volunteers. Using high-resolution manometry, we examined esophageal motor activity parameters, including esophageal body contractions and lower esophageal sphincter (LES) pressure. While, EGJ compliance was evaluated using a functional lumen imaging probe. Following determination of baseline values for esophageal motor activities and EGJ compliance, acotiamide at a standard dose of 300 mg/day was administered for 3 days. All measurements were performed again 2 hours after the last acotiamide administration. Results In the healthy volunteers, as compared with the baseline values, acotiamide administration did not significantly change esophageal body contractions and LES pressure. And EGJ distensibility was not significantly changed (distensibility index in 40-mL distension: 3.5 ± 0.4 vs 3.3 ± 0.5 mm2/mmHg). Similarly in the GERD patients, there were no differences in either esophageal motility or EGJ compliance between before and after acotiamide administration (distensibility index in 40-mL distension: 6.2 ± 0.5 vs 6.5 ± 1.1 mm2/mmHg). Conclusion In both healthy individuals and GERD patients, standard dose acotiamide dose does not have significant effects on esophageal motor activities or EGJ compliance.

참고문헌 (35)

참고문헌 신청

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