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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 502 - 507 (6page)
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초록· 키워드
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Translation is a costly, but inevitable, cell maintenance process. To reduce unnecessary ATP consumption in cells, a fine-tuning mechanism is needed for both ribosome biogenesis and translation. Previous studies have suggested that the ribosome functions as a hub for many cellular signals such as ribotoxic stress response, mammalian target of rapamycin (mTOR), and ribosomal S6 kinase (RSK) signaling. Therefore, we investigated the relationship between ribosomes and mitogen-activated protein kinase (MAPK) activation under ribotoxic stress conditions and found that the activation of c-Jun N-terminal kinases (JNKs) was suppressed by ribosomal protein knockdown but that of p38 was not. In addition, we found that JNK activation is driven by the association of inactive JNK in the 80S monosomes rather than the polysomes. Overall, these data suggest that the activation of JNKs by ribotoxic stress is attributable to 80S monosomes. These 80S monosomes are active ribosomes that are ready to initiate protein translation, rather than polysomes that are already acting ribosomes involved in translation elongation.
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참고문헌 (37)
참고문헌 신청
Klein S / 1996 / Characterization of fibroblast growth factor-2 binding to ribosomes / Growth Factors 13:219~228
Stolovich M / 2002 / Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation / Mol Cell Biol 22:8101~8113
Jetzt AE / 2012 / A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells / Int J Biochem Cell Biol 44:2204~2211
Chauvin C / 2014 / Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program / Oncogene 33:474~483
Mahoney SJ / 2009 / Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation / Prog Mol Biol Transl Sci 90:53~107
Stolovich M / 2002 / Transduction of growth or mitogenic signals into translational activation of TOP mRNAs is fully reliant on the phosphatidylinositol 3-kinase-mediated pathway but requires neither S6K1 nor rpS6 phosphorylation / Mol Cell Biol 22:8101~8113
Jetzt AE / 2012 / A relatively low level of ribosome depurination by mutant forms of ricin toxin A chain can trigger protein synthesis inhibition, cell signaling and apoptosis in mammalian cells / Int J Biochem Cell Biol 44:2204~2211
Chauvin C / 2014 / Ribosomal protein S6 kinase activity controls the ribosome biogenesis transcriptional program / Oncogene 33:474~483
Mahoney SJ / 2009 / Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation / Prog Mol Biol Transl Sci 90:53~107
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