호르몬 수용체 약양성 유방암과 삼중음성 유방암의 치료 예후

윤미란; 류지영; 송병주; 채병주; 유태경

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자료유형: 학술저널

저자정보: 윤미란 류지영 송병주 채병주 유태경

저널정보: 한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제7권 제1호

발행연도: 2019.1

수록면: 1 - 8 (8page)

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연구배경

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연구방법

🏆

연구결과

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Purpose: In breast cancer, response to endocrine therapy depends on estrogen receptor and progesterone receptor status. However, poor prognosis is conferred on patients with hormone receptor (HR)-positive breast cancer. We aimed to examine weakly positive HR breast cancer by comparing weakly positive HR to strongly positive HR and negative HR breast cancer. Methods: We examined the clinical and biological features of 1,496 women with breast cancer, and these patients were categorized according to HR status as weakly positive, strongly positive, and negative HR breast cancer. Results: In this study, among 1,496 patients with breast cancer, negative HR breast cancer was found in 374, weakly positive HR breast cancer in 90 and strongly positive HR breast cancer in 1,032 patients. Our multivariate analysis showed that there were differences in T stage, tumor–node–metastasis stage, vascular invasion, histologic grade and type, and Ki-67 index. Patients with weakly positive HR breast cancer had an increased risk of death and recurrence compared with those with strongly positive HR breast cancer and had similar prognosis as patients with negative HR breast cancer. Conclusion: Patients with weakly positive HR breast cancer received endocrine therapy because they were regarded as having positive HR breast cancer. However, their prognosis of overall survival and relapse-free survival was similar to that in patients with negative HR breast cancer. Therefore, we need to closely observe and consider active treatment for patients with weakly positive breast cancer.

참고문헌 (22)

참고문헌 신청

김지선 / 2015 / The Basic Facts of Korean Breast Cancer in 2012: Results from a Nationwide Survey and Breast Cancer Registry Database / Journal of Breast Cancer 18(2):103~111

Allred DC / 1990 / Immunocytochemical analysis of estrogen receptors in human breast carcinomas. Evaluation of 130 cases and review of the literature regarding concordance with biochemical assay and clinical relevance / Arch Surg 125:107~113

Arpino G / 2005 / Estrogen receptor-positive, progesterone receptor-negative breast cancer: association with growth factor receptor expression and tamoxifen resistance / J Natl Cancer Inst 97:1254~1261

Bae SY / 2015 / Poor prognosis of single hormone receptor- positive breast cancer: similar outcome as triple-negative breast cancer / BMC Cancer 15:138

Iwamoto T / 2012 / Estrogen receptor (ER) mRNA and ER-related gene expression in breast cancers that are 1% to 10% ER-positive by immunohistochemistry / J Clin Oncol 30:729~734

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