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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 168 - 174 (7page)
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초록· 키워드
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Background/Aims: Pathological diagnosis of biliary strictures with atypical or suspicious cells on endoscopic retrograde brush cytologyand indeterminate strictures on imaging is challenging. The aim of this study was to identify markers for malignant strictures in suchcases. Methods: We retrospectively analyzed data collected from 146 consecutive patients with indeterminate biliary strictures on imagingwho underwent endoscopic retrograde brush cytology from 2007 to 2013. Factors associated with malignant strictures in patients withatypical or suspicious cells on brush cytology were identified. Results: Among the 67 patients with a malignant disease (48 cholangiocarcinoma, 6 gallbladder cancer, 5 pancreatic cancer, 5 ampullaof Vater cancer, and 3 other types), 36 (53.7%) had atypical or suspicious cells on brush cytology. Among these, the factors thatindependently correlated with malignant strictures were stricture length (odds ratio [OR], 5.259; 95% confidence interval [CI], 1.802–15.294) and elevated carbohydrate antigen 19-9 (CA19-9) (OR, 3.492; 95% CI, 1.242–9.815), carcinoembryonic antigen (CEA) (OR, 4.909;95% CI, 1.694–14.224), alkaline phosphatase (ALP) (OR, 3.362; 95% CI, 1.207–9.361), and gamma-glutamyl transpeptidase (rGT) (OR,4.318; 95% CI, 1.512–12.262). Conclusions: Elevated levels of CA19-9, CEA, ALP, and rGT and stricture length are associated with malignant strictures in patientswith indeterminate biliary strictures on imaging and atypical or suspicious cells on brush cytology.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Mahmoudi N / 2008 / Biliary brush cytology : factors associated with positive yields on biliary brush cytology / World J Gastroenterol 14:569~573
Hiroki Tanaka / 2018 / Usefulness of Endoscopic Transpapillary Tissue Sampling for Malignant Biliary Strictures and Predictive Factors of Diagnostic Accuracy / Clinical Endoscopy 51(2):174~180
Parsi MA / 2011 / Factors affecting the yield of brush cytology for the diagnosis of pancreatic and biliary cancers / Pancreas 40:52~54
Kawada N / 2011 / Combined brush cytology and stent placement in a single session for presumed malignant biliary stricture / J Gastroenterol Hepatol 26:1247~1251
Navaneethan U / 2014 / Predictors for detection of cancer in patients with indeterminate biliary stricture and atypical cells on endoscopic retrograde brush cytology / J Dig Dis 15:268~275
Hiroki Tanaka / 2018 / Usefulness of Endoscopic Transpapillary Tissue Sampling for Malignant Biliary Strictures and Predictive Factors of Diagnostic Accuracy / Clinical Endoscopy 51(2):174~180
Parsi MA / 2011 / Factors affecting the yield of brush cytology for the diagnosis of pancreatic and biliary cancers / Pancreas 40:52~54
Kawada N / 2011 / Combined brush cytology and stent placement in a single session for presumed malignant biliary stricture / J Gastroenterol Hepatol 26:1247~1251
Navaneethan U / 2014 / Predictors for detection of cancer in patients with indeterminate biliary stricture and atypical cells on endoscopic retrograde brush cytology / J Dig Dis 15:268~275
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