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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 116 - 124 (9page)
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Purpose: Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine monophosphate response elementbinding protein (CREB)/brain-derived neurotrophic factor (BDNF) and c-Raf/mitogen-activated protein kinases-extracellular signal–regulated kinases (MEK)/extracellular signal–regulated kinases (ERK) pathways in the hippocampus. Methods: Orchiectomy was performed for surgical castration and goserelin acetate was subcutaneously transplanted into the anterior abdominal wall for chemical castration. Immunohistochemistry was done to quantify neurogenesis. To assess the involvement of the PKA/CREB/BDNF and c-Raf/MEK/ERK pathways in the memory process, western blots were used. Results: The orchiectomy group and the goserelin group showed less neurogenesis and impaired short-term and spatial memory. Phosphorylation of PKA/CREB/BDNF and phosphorylation of c-Raf/MEK/ERK decreased in the orchiectomy and goserelin groups. Conclusions: Short-term memory and spatial memory were affected by surgical and chemical castration via the PKA/CREB/ BDNF and c-Raf/MEK/ERK signaling pathways.
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등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Lehmusvaara S / 2012 / Chemical castration and anti-androgens induce differential gene expression in prostate cancer / J Pathol 227:336~345
Kritzer MF / 2001 / Gonadectomy impairs T-maze acquisition in adult male rats / Horm Behav 39:167~174
Daniel JM / 2003 / Castration in rats impairs performance during acquisition of a working memory task and exacerbates deficits in working memory produced by scopolamine and mecamylamine / Psychopharmacology(Berl) 170:294~300
Shin MS / 2013 / Treadmill exercise ameliorates symptoms of methimazole-induced hypothyroidism through enhancing neurogenesis and suppressing apoptosis in the hippocampus of rat pups / Int J Dev Neurosci 31:214~223
Spritzer MD / 2007 / Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats / Dev Neurobiol 67:1321~1333
Kritzer MF / 2001 / Gonadectomy impairs T-maze acquisition in adult male rats / Horm Behav 39:167~174
Daniel JM / 2003 / Castration in rats impairs performance during acquisition of a working memory task and exacerbates deficits in working memory produced by scopolamine and mecamylamine / Psychopharmacology(Berl) 170:294~300
Shin MS / 2013 / Treadmill exercise ameliorates symptoms of methimazole-induced hypothyroidism through enhancing neurogenesis and suppressing apoptosis in the hippocampus of rat pups / Int J Dev Neurosci 31:214~223
Spritzer MD / 2007 / Testosterone and dihydrotestosterone, but not estradiol, enhance survival of new hippocampal neurons in adult male rats / Dev Neurobiol 67:1321~1333
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