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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제2호
- 발행연도
- 2019.1
- 수록면
- 203 - 214 (12page)
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초록· 키워드
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Liposomes have been long used in cancer therapy with great expectations that they can improve efficacy mainly through enhanced permeation and retention (EPR) effect and reduce toxicity related to un-encapsulated anticancer agents. However, the advantage of liposomal formulations has not been prominent as anticipated in clinical cancer treatment in contrast to preclinical results and this has led nanomedicine field to review the experiences of liposomal anticancer products so far to pursue better strategies. The aim of this review is to look for answers to the questions whether liposomes really increase efficacy and reduce toxicity of encapsulated drugs in humans by consulting recent several meta-analyses. Based on the metaanalyses, liposomal formulations have shown comparable or modestly superior clinical efficacy compared to non-liposomal conventional formulations. Besides, drug-related toxicity, for example, cardiotoxicity of doxorubicin, has been clearly reduced by encapsulation of cytotoxic agents into liposomes despite carrier-related adverse events are newly occurred. In conclusion, liposomes are clinically useful in cancer therapy and their value can be raised by applying more advanced and elaborate strategies through understanding tumor microenvironment.
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참고문헌 (56)
참고문헌 신청
Anders CK / 2013 / Pharmacokinetics and efficacy of PEGylated liposomal doxorubicin in an intracranial model of breast cancer / PLoS One 8(5):e61359
Bangham AD / 1965 / Diffusion of univalent ions across the lamellae of swollen phospholipids / J Mol Biol 13(1):238~252
Barenholz Y / 2012 / Doxil®(R)--the first FDA-approved nano-drug : lessons learned / J Control Release 160(2):117~134
Baselga J / 2014 / Phase III trial of nonPEGylated liposomal doxorubicin in combination with trastuzumab and paclitaxel in HER2-positive metastatic breast cancer / Ann Oncol 25(3):592~598
Batist G / 2001 / Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer / J Clin Oncol 19(5):1444~1454
Bangham AD / 1965 / Diffusion of univalent ions across the lamellae of swollen phospholipids / J Mol Biol 13(1):238~252
Barenholz Y / 2012 / Doxil®(R)--the first FDA-approved nano-drug : lessons learned / J Control Release 160(2):117~134
Baselga J / 2014 / Phase III trial of nonPEGylated liposomal doxorubicin in combination with trastuzumab and paclitaxel in HER2-positive metastatic breast cancer / Ann Oncol 25(3):592~598
Batist G / 2001 / Reduced cardiotoxicity and preserved antitumor efficacy of liposome-encapsulated doxorubicin and cyclophosphamide compared with conventional doxorubicin and cyclophosphamide in a randomized, multicenter trial of metastatic breast cancer / J Clin Oncol 19(5):1444~1454
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