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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제45권 제1호
- 발행연도
- 2015.2
- 수록면
- 73 - 78 (6page)
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초록· 키워드
오류제보하기
Multilamellar vesicle (MLV)-type liposomesare promising carriers for hydrophobic drugs that need tobe injected. In MLV preparation process, probe sonicationstep is often required to obtain liposomes fulfilling themean particle size and polydispersity index (PI) requirementsas an injectable lipid formulation. However, it isoften limited by the risk of sample overheating. This studywas undertaken to explore a possibility of using cell disruptorin the liposome preparation process as an alternativesonication method. Use of cell disruptor-type sonicatordecreased the mean particle size and PI of liposomes muchmore effectively compared to conventional bath sonicators.
The effectiveness of cell disruptor sonicator in decreasingthe size and PI of liposomes was comparable to that ofprobe sonicator, particularly in the presence of a hydrophobicdrug celecoxib. Sonication of liposomes by a celldisruptor sonicator produced celecoxib-loaded liposomesexhibiting 152 ± 9 nm mean particle size with a PI of0.155, indicating a very homogenous and fine dispersion.
Together with its proved efficacy in increasing the homogeneity,the advantage of cell disruptor sonicator includesthe minimal exposure of liposome samples to heat, therebyproviding an efficient method to prepare injectable liposomesat a laboratory scale.
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참고문헌 (20)
참고문헌 신청
Akbarzadeh A / 2013 / Liposome: classification, preparation, and application / Nanoscale Res Lett 8(1):102
Basile L / 2012 / Serum-stable, long-circulating paclitaxelloaded colloidal carriers decorated with a new amphiphilic PEG derivative / Int J Pharm 426(2):231~238
Bhardwaj U / 2010 / Physicochemical properties of extruded and non-extruded liposomes containing the hydrophobic drug dexamethasone / Int J Pharm 388(1):181~190
Copeland RA / 2006 / Drug-target residence time and its implications for lead optimization / Nat Rev Drug Discov 5(9):730~739
Dickson D / 2012 / Dispersion and stability of bare hematite nanoparticles: effect of dispersion tools, nanoparticle concentration, humic acid and ionic strength / Sci Total Environ 419:170~177
Basile L / 2012 / Serum-stable, long-circulating paclitaxelloaded colloidal carriers decorated with a new amphiphilic PEG derivative / Int J Pharm 426(2):231~238
Bhardwaj U / 2010 / Physicochemical properties of extruded and non-extruded liposomes containing the hydrophobic drug dexamethasone / Int J Pharm 388(1):181~190
Copeland RA / 2006 / Drug-target residence time and its implications for lead optimization / Nat Rev Drug Discov 5(9):730~739
Dickson D / 2012 / Dispersion and stability of bare hematite nanoparticles: effect of dispersion tools, nanoparticle concentration, humic acid and ionic strength / Sci Total Environ 419:170~177
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