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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제49권 제3호
- 발행연도
- 2019.1
- 수록면
- 279 - 285 (7page)
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초록· 키워드
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Vaccine adjuvants enhance immunogenic responses of antigens and increase potency of vaccines. Physicochemical properties of particulate vaccine adjuvants namely, particle size, surface charge, hydrophobicity, shape and composition play an important role to determine their activity and potency. Various studies have been done using different types of particulate vaccine adjuvants to correlate their physicochemical properties with immune responses. Generally, change in particle size does not show any trend in modulation of immunogenicity, however, it directly influences on cellular uptake of particles, leading to alteration of cytokine profile and induction of Th1 and/or Th2 responses. Usually, positively charged adjuvant particles undergo higher cellular uptake than negatively charged particles and hydrophobic particles undergo cellular uptake more efficiently than hydrophilic particles. Furthermore, shape and composition of adjuvant particles also influence on immune responses. This review gives an insight into the impact of particle size, surface charge, hydrophobicity, shape and composition of particulate vaccine adjuvants in modulating immune responses.
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참고문헌 (40)
참고문헌 신청
Agarwal R / 2013 / Mammalian cells preferentially internalize hydrogel nanodiscs over nanorods and use shape-specific uptake mechanisms / Proc Natl Acad Sci 110:17247~17252
Akagi T / 2012 / Polymers in nanomedicine / Springer :31~64
Aucouturier J / 2001 / Adjuvants designed for veterinary and human vaccines / Vaccine 19:2666~2672
Badiee A / 2012 / The role of liposome size on the type of immune response induced in BALB/c mice against leishmaniasis : rgp63 as a model antigen / Exp Parasitol 132:403~409
Rakesh Bastola / 2017 / Vaccine adjuvants: smart components to boost the immune system / Archives of Pharmacal Research 40(11):1238~1248
Akagi T / 2012 / Polymers in nanomedicine / Springer :31~64
Aucouturier J / 2001 / Adjuvants designed for veterinary and human vaccines / Vaccine 19:2666~2672
Badiee A / 2012 / The role of liposome size on the type of immune response induced in BALB/c mice against leishmaniasis : rgp63 as a model antigen / Exp Parasitol 132:403~409
Rakesh Bastola / 2017 / Vaccine adjuvants: smart components to boost the immune system / Archives of Pharmacal Research 40(11):1238~1248
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