지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 1 - 13 (13page)
이용수
초록· 키워드
오류제보하기
Acetate has been indicated to be elevated and to regulate inflammation in inflammatory and metabolic diseases. The inflammasome serves as a key component of immune homeostasis, and its dysregulation can lead to various inflammatory disorders. However, little is known about the effects of acetate on inflammasome activation and the underlying mechanism. Here, we demonstrate that acetate attenuates inflammasome activation via GPR43 in a Ca2+-dependent manner. Through binding to GPR43, acetate activates the Gq/11 subunit and subsequent phospholipase C-IP3 signaling to decrease Ca2+ mobilization. In addition, acetate activates soluble adenylyl cyclase (sAC), promotes NLRP3 inflammasome ubiquitination by PKA, and ultimately induces NLRP3 degradation through autophagy. In vivo, acetate protects mice from NLRP3 inflammasome-dependent peritonitis and LPS-induced endotoxemia. Collectively, our research demonstrates that acetate regulates the NLRP3 inflammasome via GPR43 and Ca2+-dependent mechanisms, which reveals the mechanism of metabolite-mediated NLRP3 inflammasome attenuation and highlights acetate as a possible therapeutic strategy for NLRP3 inflammasome-related diseases.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Publisher Correction: Acetate attenuates inflammasome activation through GPR43- mediated Ca2+-dependent NLRP3 ubiquitination
Experimental and Molecular Medicine
2019 .01
-
Mitophagy: a balance regulator of NLRP3 inflammasome activation
BMB Reports
2016 .01
-
The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3
Experimental and Molecular Medicine
2019 .01
-
STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation
Experimental and Molecular Medicine
2024 .09
-
The activation of NLRP3 inflammasome potentiates the immunomodulatory abilities of mesenchymal stem cells in a murine colitis model
BMB Reports
2020 .01
-
NLRP3 inflammasome: a key player in the pathogenesis of life-style disorders
Experimental and Molecular Medicine
2024 .07
-
Autophagy down-regulates NLRP3-dependent inflammatory response of intestinal epithelial cells under nutrient deprivation
BMB Reports
2021 .01
-
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis
Experimental and Molecular Medicine
2022 .02
-
Anti-inflammatory effects of N-cyclooctyl-5-methylthiazol-2-amine hydrobromide on lipopolysaccharide-induced inflammatory response through attenuation of NLRP3 activation in microglial cells
BMB Reports
2021 .11
-
Cancer-derived exosomal Alu RNA promotes colorectal cancer progression
Experimental and Molecular Medicine
2024 .03
-
Inhibition of Caspase-1 Activation by Inflammasome through ASC-targeting Protein Binder
한국생물공학회 학술대회
2022 .09
-
Effects of α-lipoic acid on LPS-induced neuroinflammation and NLRP3 inflammasome activation through the regulation of BV-2 microglial cells activation
BMB Reports
2019 .01
-
Selection of Enzyme and Molar Ratio for Enzymatic Production of Phenethyl Acetate
한국생물공학회 학술대회
2015 .10
-
Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages
BMB Reports
2016 .01
-
Adding Acetate into a Substrate Profile of an Efficient Glucose/Xylose Co-fermenting Saccharomyces cerevisiae for Lignocellulosic Biorefinery
한국생물공학회 학술대회
2021 .04
-
혼합영양 배양조건에서의 Anabena 배양을 위한 유기탄소(acetate 종류 및 농도) 선정 연구
화학공학
2018 .01
-
Improvement of itaconate production in Escherichia coli using acetate as a substrate
한국생물공학회 학술대회
2019 .10
-
Remove of acetate using membrane electrolysis from carbon monoxide fermentation broth.
한국생물공학회 학술대회
2018 .04
-
Engineering of Glyoxylate Cycle for Efficient Tyrosine Production from Acetate in Escherichia coli
한국생물공학회 학술대회
2021 .10
-
Crosstalk between the heart and peripheral organs in heart failure
Experimental and Molecular Medicine
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0