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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 260 - 265 (6page)
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Dysregulation of inflammation induced by noninfectious stress conditions, such as nutrient deprivation, causes tissue damage and intestinal permeability, resulting in the development of inflammatory bowel diseases. We studied the effect of autophagy on cytokine secretion related to intestinal permeability under nutrient deprivation. Autophagy removes NLRP3 inflammasomes via ubiquitin-mediated degradation under starvation. When autophagy was inhibited, starvation-induced NLRP3 inflammasomes and their product, IL-1β, were significantly enhanced. A prolonged nutrient deprivation resulted in an increased epithelial mesenchymal transition (EMT), leading to intestinal permeability. Under nutrient deprivation, IL-17E/25, which is secreted by IL-1β, demolished the intestinal epithelial barrier. Our results suggest that an upregulation of autophagy maintains the intestinal barrier by suppressing the activation of NLRP3 inflammasomes and the release of their products, including proinflammatory cytokines IL-1β and IL-17E/25, under nutrient deprivation.
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참고문헌 (28)
참고문헌 신청
Vaziri ND / 2013 / Chronic kidney disease causes disruption of gastric and small intestinal epithelial tight junction / Am J Nephrol 38:99~103
Tabat MW / 2020 / Acute effects of butyrate on induced hyperpermeability and tight junction protein expression in human colonic tissues / Biomolecules 10:766
Zareie M / 2006 / Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress / Gut 55:1553~1560
Kiesslich R / 2012 / Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease / Gut 61:1146~1153
Bouma G / 1997 / Evidence for genetic heterogeneity in inflammatory bowel disease(IBD); HLA genes in the predisposition to suffer from ulcerative colitis(UC)and Crohn’s disease(CD) / Clin Exp Immunol 109:175~179
Tabat MW / 2020 / Acute effects of butyrate on induced hyperpermeability and tight junction protein expression in human colonic tissues / Biomolecules 10:766
Zareie M / 2006 / Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress / Gut 55:1553~1560
Kiesslich R / 2012 / Local barrier dysfunction identified by confocal laser endomicroscopy predicts relapse in inflammatory bowel disease / Gut 61:1146~1153
Bouma G / 1997 / Evidence for genetic heterogeneity in inflammatory bowel disease(IBD); HLA genes in the predisposition to suffer from ulcerative colitis(UC)and Crohn’s disease(CD) / Clin Exp Immunol 109:175~179
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