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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제5호
- 발행연도
- 2019.1
- 수록면
- 776 - 784 (9page)
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초록· 키워드
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Polyhydroxybutyrate (PHB), the most well-known polyhydroxyalkanoate, is a bio-based, biodegradable polymer that has the potential to replace petroleum-based plastics. Lignocellulose hydrolysate, a non-edible resource, is a promising substrate for the sustainable, fermentative production of PHB. However, its application is limited by the generation of inhibitors during the pretreatment processes. In this study, we investigated the feasibility of PHB production in E. coli in the presence of inhibitors found in lignocellulose hydrolysates. Our results show that the introduction of PHB synthetic genes (bktB, phaB, and phaC from Ralstonia eutropha H16) improved cell growth in the presence of the inhibitors such as furfural, 4-hydroxybenzaldehyde, and vanillin, suggesting that PHB synthetic genes confer resistance to these inhibitors. In addition, increased PHB production was observed in the presence of furfural as opposed to the absence of furfural, suggesting that this compound could be used to stimulate PHB production. Our findings indicate that PHB production using lignocellulose hydrolysates in recombinant E. coli could be an innovative strategy for cost-effective PHB production, and PHB could be a good target product from lignocellulose hydrolysates, especially glucose.
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참고문헌 (48)
참고문헌 신청
Ragauskas AJ / 2006 / The path forward for biofuels and biomaterials / Science 311:484~489
Lynd LR / 2008 / How biotech can transform biofuels / Nat. Biotechnol 26:169~172
Sims RE / 2010 / An overview of second generation biofuel technologies / Bioresour. Technol 101:1570~1580
Brodin M / 2017 / Lignocellulosics as sustainable resources for production of bioplastics-a review / J. Clean Prod 162:646~664
Sharma HK / 2017 / Biological pretreatment of lignocellulosic biomass for biofuels and bioproducts : an overview / Waste and Biomass Valorization :1~17
Lynd LR / 2008 / How biotech can transform biofuels / Nat. Biotechnol 26:169~172
Sims RE / 2010 / An overview of second generation biofuel technologies / Bioresour. Technol 101:1570~1580
Brodin M / 2017 / Lignocellulosics as sustainable resources for production of bioplastics-a review / J. Clean Prod 162:646~664
Sharma HK / 2017 / Biological pretreatment of lignocellulosic biomass for biofuels and bioproducts : an overview / Waste and Biomass Valorization :1~17
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