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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 245 - 251 (7page)
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Ependymal cells constitute the multi-ciliated epithelium, which lines the brain ventricular lumen. Although ependymal cells originate from radial glial cells in the perinatal rodent brain, the exact mechanisms underlying the full differentiation of ependymal cells are poorly understood. In this report, we present evidence that the Anks1a phosphotyrosine binding domain (PTB) adaptor is required for the proper development of ependymal cells in the rodent postnatal brain. Anks1a gene trap targeted LacZ reporter analysis revealed that Anks1a is expressed prominently in the ventricular region of the early postnatal brain and that its expression is restricted to mature ependymal cells during postnatal brain development. In addition, Anks1a-deficient ependymal cells were shown to possess type B cell characteristics, suggesting that ependymal cells require Anks1a in order to be fully differentiated. Finally, Anks1a overexpression in the lateral wall of the neonatal brain resulted in an increase in the number of ependymal cells during postnatal brain development. Altogether, our results suggest that ependymal cells require Anks1a PTB adaptor for their proper development.
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참고문헌 (30)
참고문헌 신청
Bayly, R. / 2011 / Pointing in the right direction : New developments in the field of planar cell polarity / Nat. Rev. Genet 12:385~391
Carlen, M. / 2009 / Forebrain ependymal cells are notch-dependent and generate neuroblasts and astrocytes after stroke / Nat. Neurosci 12:259~267
Codega, P. / 2014 / Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche / Neuron 82:545~559
Conover, J. C. / 2000 / Disruption of eph/ephrin signaling affects migration and proliferation in the adult subventricular zone / Nat. Neurosci 3:1091~1097
De Rubeis, S. / 2014 / Synaptic, transcriptional and chromatin genes disrupted in autism / Nature 515:209~215
Carlen, M. / 2009 / Forebrain ependymal cells are notch-dependent and generate neuroblasts and astrocytes after stroke / Nat. Neurosci 12:259~267
Codega, P. / 2014 / Prospective identification and purification of quiescent adult neural stem cells from their in vivo niche / Neuron 82:545~559
Conover, J. C. / 2000 / Disruption of eph/ephrin signaling affects migration and proliferation in the adult subventricular zone / Nat. Neurosci 3:1091~1097
De Rubeis, S. / 2014 / Synaptic, transcriptional and chromatin genes disrupted in autism / Nature 515:209~215
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