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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제23권 제1호
- 발행연도
- 2019.1
- 수록면
- 21 - 28 (8page)
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초록· 키워드
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Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride (CCl4)-induced liver injury and its possible mechanisms. Adult male Sprague Dawley rats were randomly divided into a control group, an STM 200 mg/kg group, a CCl4 group, a CCl4+STM 100 mg/kg group, and a CCl4+STM 200 mg/kg group. Rats in experimental groups were subcutaneously injected with 40% CCl4 twice weekly for 8 weeks. STM (100 and 200 mg/kg per day) was orally given to experimental rats by gavage for 8 consecutive weeks. Hepatocyte apoptosis was determined by TUNEL assay and the expression levels of Bcl-2, Bax, and cleaved caspase-3 proteins were evaluated by western blot analysis. The expression of TGF- 1, collagen I, collagen III, CTGF and fibronectin mRNA were estimated by qRT-PCR. The results showed that STM significantly reduced the number of TUNEL-positive cells compared with the CCl4 group. The levels of Bax and cleaved caspase-3 proteins, and TGF- 1, collagen I, collagen III, CTGF, and fibronectin mRNA were significantly reduced by STM compared with the CCl4 group. In addition, STM markedly abrogated the repression of Bcl-2 by CCl4. STM also attenuated the activation of the PI3K/Akt pathway in the liver. These results suggested that STM ameliorated CCl4-induced hepatocyte apoptosis in rats.
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참고문헌 (39)
참고문헌 신청
Delire B / 2015 / Animal models for fibrotic liver diseases : What we have, what we need, and what is under development / J Clin Transl Hepatol 3:53~66
Liu T / 2012 / Molecular serum markers of liver fibrosis / Biomark Insights 7:105~117
Cohen-Naftaly M / 2011 / Current status of novel antifibrotic therapies in patients with chronic liver disease / Therap Adv Gastroenterol 4:391~417
Geerts A / 2001 / History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells / Semin Liver Dis 21:311~335
Cassiman D / 2002 / Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers / J Hepatol 36:200~209
Liu T / 2012 / Molecular serum markers of liver fibrosis / Biomark Insights 7:105~117
Cohen-Naftaly M / 2011 / Current status of novel antifibrotic therapies in patients with chronic liver disease / Therap Adv Gastroenterol 4:391~417
Geerts A / 2001 / History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells / Semin Liver Dis 21:311~335
Cassiman D / 2002 / Hepatic stellate cell/myofibroblast subpopulations in fibrotic human and rat livers / J Hepatol 36:200~209
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