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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 152 - 156 (5page)
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Background: CC chemokine ligand 17 (CCL17) and CCL22are the functional ligands for CCR4. We previously reportedthat inhibitors of nuclear factor-kappa B and p38 mitogen-activated protein kinase (p38 MAPK), but not of extracellularsignal-related kinase (ERK), inhibited tumor necrosisfactor (TNF)-α- and interferon (IFN)-γ-induced productionof CCL17 by the human keratinocyte cell line,HaCaT. Further, an inhibitor of epidermal growth factor receptor(EGFR) enhanced the CCL17 production by thesekeratinocytes. Objective: To identify the mechanism underlyingCCL22 production by HaCaT cells. Methods: We investigatedthe signal transduction pathways by which TNF-αand IFN-γ stimulate HaCaT cells to produce CCL22 by addingvarious inhibitors. Results: TNF-α- and IFN-γ- inducedCCL22 production was inhibited by PD98059, PD153035,Bay 11-7085, SB202190, c-Jun N-terminal kinase (JNK) inhibitorII, and Janus kinase (JAK) inhibitor 1. Conclusion: Ourresults indicate that CCL22 production in HaCaT cells is dependenton ERK, EGFR, p38 MAPK, JNK, and JAK and ismediated by different signal pathways from those regulatingCCL17 production. Altogether, our previous and present resultssuggest that EGFR activation represses CCL17 but enhancesCCL22 production by these cells.
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참고문헌 (16)
참고문헌 신청
Goh KC / 1999 / p38 MAP kinase is required for STAT1 serine phosphorylation and transcriptional activation induced by interferons / EMBO J 18 : 5601 ~ 5608
Holvoet S / 2003 / The inhibition of MAPK pathway is correlated with down-regulation of MMP-9 secretion induced by TNF-alpha in human keratinocytes / Exp Cell Res 290 : 108 ~
Horikawa T / 2002 / IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and th
Iordanov MS / 2002 / The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling
Kobayashi M / 2004 / Roxithromycin downmodulates Th2 chemokine production by keratinocytes and chemokine receptor expression on Th2 cells: its dual inhibitory effects on the
Holvoet S / 2003 / The inhibition of MAPK pathway is correlated with down-regulation of MMP-9 secretion induced by TNF-alpha in human keratinocytes / Exp Cell Res 290 : 108 ~
Horikawa T / 2002 / IFN-gamma-inducible expression of thymus and activation-regulated chemokine/CCL17 and macrophage-derived chemokine/CCL22 in epidermal keratinocytes and th
Iordanov MS / 2002 / The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling
Kobayashi M / 2004 / Roxithromycin downmodulates Th2 chemokine production by keratinocytes and chemokine receptor expression on Th2 cells: its dual inhibitory effects on the
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