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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국미생물생명공학회 Journal of Microbiology and Biotechnology Journal of Microbiology and Biotechnology 제29권 제5호
- 발행연도
- 2019.1
- 수록면
- 704 - 712 (9page)
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초록· 키워드
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Although nanometric dead Lactobacillus plantarum has emerged as a potentially important modulator of immune responses, its underlying mechanism of action has not been fully understood. This study aimed to identify the detailed biochemical mechanism of immune modulation by micronized and heat-treated L. plantarum LM1004 (MHT-LM1004, <1 μm in size). MHT-LM1004 was prepared from L. plantarum LM1004 via culture in a specifically designed membrane bioreactor and heat treatment. MHT-LM1004 was shown to effectively induce the secretion of TNF-α and IL-6 and the mRNA expression of inducible nitric oxide synthase (iNOS). MHT-LM1004 enhanced the expression of TLR-2, phosphorylation of MAPKs (ERK), and nuclear translocation of NF-κB in a dose-dependent manner. Oral administration of MHT-LM1004 (4 × 109 or 4× 1011 cells/kg mouse body weight) increased the splenocyte proliferation and serum cytokine levels. These results suggested that MHT-LM1004 effectively enhances early innate immunity by activating macrophages via the TLR-2/MAPK/NF-κB signalling pathway and that this pathway is one of the major routes in immune modulation by the Lactobacillus species.
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참고문헌 (30)
참고문헌 신청
황준호 / 2017 / Immunostimulatory Activity of Opuntia ficus-indica var. Saboten Cladodes Fermented by Lactobacillus plantarum and Bacillus subtilis in RAW 264.7 Macrophages / Journal of Medicinal Food 20(2):131~139
Adams CA / 2010 / The probiotic paradox : live and dead cells are biological response modifiers / Nutr. Res. Rev 23:37~46
Aoki-Yoshida A / 2017 / Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro / Biochem. Biophys. Res. Commun 489:248~254
Chuang L / 2007 / Heat-killed cells of lactobacilli skew the immune response toward T helper 1 polarization in mouse splenocytes and dendritic cell-treated T cells / J. Agr. Food Chem 55:11080~11086
He F / 2005 / Effect of orally administered nonviable Lactobacillus cells on murine humoral immune responses / Microbiol. Immunol 49:995~999
Adams CA / 2010 / The probiotic paradox : live and dead cells are biological response modifiers / Nutr. Res. Rev 23:37~46
Aoki-Yoshida A / 2017 / Exosomes isolated from sera of mice fed Lactobacillus strains affect inflammatory cytokine production in macrophages in vitro / Biochem. Biophys. Res. Commun 489:248~254
Chuang L / 2007 / Heat-killed cells of lactobacilli skew the immune response toward T helper 1 polarization in mouse splenocytes and dendritic cell-treated T cells / J. Agr. Food Chem 55:11080~11086
He F / 2005 / Effect of orally administered nonviable Lactobacillus cells on murine humoral immune responses / Microbiol. Immunol 49:995~999
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