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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 530 - 545 (16page)
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Tumor cells can vary epigenetically during ionizing irradiation (IR) treatment. These epigenetic variegations can influence IR response and shape tumor aggressiveness. However, epigenetic disturbance of histones after IR, implicating in IR responsiveness, has been elusive. Here, we investigate whether altered histone modification after IR can influence radiation responsiveness. The oncogenic CXCL12 mRNA and protein were more highly expressed in residual cancer cells from a hepatoma heterotopic murine tumor microenvironment and coculture of human hepatoma Huh7 and normal IMR90 cells after radiation. H3K4 methylation was also enriched and H3K9 methylation was decreased at its promoter region. Accordingly, invasiveness and the subpopulation of aggressive CD133+/CD24– cells increased after IR. Histone demethylase inhibitor IOX1 attenuated CXCL12 expression and the malignant subpopulation, suggesting that responses to IR can be partially mediated via histone modifications. Taken together, radiation-induced histone alterations at the CXCL12 promoter in hepatoma cells are linked to CXCL12 upregulation and increased aggressiveness in the tumor microenvironment.
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참고문헌 (31)
참고문헌 신청
Ahuja, N. / 2014 / Harnessing the potential of epigenetic therapy to target solid tumors / J. Clin. Invest 124:56~63
Bao, S. / 2006 / Glioma stem cells promote radioresistance by preferential activation of the DNA damage response / Nature 444:756~760
Chatterjee, S. / 2014 / The intricate role of CXCR4 in cancer / Adv. Cancer Res 124:31~82
Jae Duk Choi / 2013 / Interplay between Epigenetics and Genetics in Cancer / Genomics & Informatics 11(4):164
Dobrynin, G. / 2017 / KDM4A regulates HIF-1levels through H3K9me3 / Sci. Rep 11:11094
Bao, S. / 2006 / Glioma stem cells promote radioresistance by preferential activation of the DNA damage response / Nature 444:756~760
Chatterjee, S. / 2014 / The intricate role of CXCR4 in cancer / Adv. Cancer Res 124:31~82
Jae Duk Choi / 2013 / Interplay between Epigenetics and Genetics in Cancer / Genomics & Informatics 11(4):164
Dobrynin, G. / 2017 / KDM4A regulates HIF-1levels through H3K9me3 / Sci. Rep 11:11094
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