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Sargassum serratifolium ethanolic extract has been known for strong antioxidant and anti-inflammatory properties. We prepared hexane fraction from the ethanolic extract of S. serratifolium (HSS) to improve biological activities. In this study, we investigated the effects of HSS on the inhibition of tumor necrosis factor (TNF)-α-induced monocyte adhesion to human umbilical vein endothelial cells (HUVECs). We found that HSS suppressed the production of cell adhesion molecules such as intracellular adhesion molecule-1 and vascular cell adhesion molecule-1 in TNF-α-induced HUVECs. Moreover, TNF-α-induced production of monocyte chemoattractant protein 1 and keratinocyte chemoattractant was inhibited by HSS treatment. HSS suppressed TNF-α-induced nuclear factor kappa B (NF-κB) activation via preventing proteolytic degradation of inhibitor κB-α. HSS induced the production of heme oxygenase 1 via translocation of Nrf2 into the nucleus in TNF-α-treated HUVECs. Overall, HSS alleviated vascular inflammation through the downregulation of NF-κB activation and the upregulation of Nrf2 activation in TNF-α-induced HUVECs. These results indicate that HSS may be used as therapeutic agents for vascular inflammatory disorders.
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참고문헌 (30)
참고문헌 신청
Ayer A / 2016 / Heme oxygenases in cardiovascular health and disease / Physiol Rev 96:1449~1508
Azam MS / 2017 / Ethanolic extract from Sargassum serratifolium attenuates hyperpigmentation through CREB/ERK signaling pathways in α-MSH-stimulated B16F10 melanoma cells / J Appl Phycol 29:2089~2096
Catalan U / 2015 / Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells / Mol Nutri Food Res 59:2523~2536
Catapano AL / 2017 / Vascular inflammation and low-density lipoproteins : is cholesterol the link? A lesson from the clinical trials / Br J Pharmacol 174:3973~3985
Chen YM / 2004 / Dual regulation of tumor necrosis factor-α-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-κB and activator protein-1 : modulation by type III phosphodiesterase inhibition / J Pharmacol Exp Ther 309:978~986
Azam MS / 2017 / Ethanolic extract from Sargassum serratifolium attenuates hyperpigmentation through CREB/ERK signaling pathways in α-MSH-stimulated B16F10 melanoma cells / J Appl Phycol 29:2089~2096
Catalan U / 2015 / Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells / Mol Nutri Food Res 59:2523~2536
Catapano AL / 2017 / Vascular inflammation and low-density lipoproteins : is cholesterol the link? A lesson from the clinical trials / Br J Pharmacol 174:3973~3985
Chen YM / 2004 / Dual regulation of tumor necrosis factor-α-induced CCL2/monocyte chemoattractant protein-1 expression in vascular smooth muscle cells by nuclear factor-κB and activator protein-1 : modulation by type III phosphodiesterase inhibition / J Pharmacol Exp Ther 309:978~986
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