지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.6
- 수록면
- 378 - 386 (9page)
이용수
초록· 키워드
오류제보하기
Anti-atherogenic effects in tumor necrosis factor-α (TNF-α)-stimulated human umbilical vein endothelial cells (HUVEC) are involved in the suppression of oxidative stress, cell adhesion molecules, and pro-inflammatory factors. This study investigated the vascular inflammation inhibitory activity of traditional Doenjang plays a key role in the pathogenesis and progression of atherosclerosis. The protective effects of Korean Deonjang was investigated on the expression of cell adhesion molecules (CAMs) in tumor necrosis factor (TNF)-α-induced human umbilical vascular endothelial cells (HUVECs). Deonjang extracts (20, 50, 100 μg/mL) decreased the expression of 20 ng/mL TNF-α-induced vascular cell adhesion molecule (VCAM)-1 intracellular adhesion molecule (ICAM)-1 proteins, and their corresponding mRNA levels. Nitric oxides (NO) produced by endothlial nitric oxides synthase (eNOS) dilated blood vessels, which had protective effects against platelet and leukocyte adhesion. While TNF-α-induced suppressed the production of nitric oxide in HUVECs, Doenjang restored NO production in HUVECs. In addition, Deonjang reduced the TNF-α-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA levels. These results suggested that Doenjang can inhibited the production of cell adhesion molecules and inflammatory mediators, which could be a potential candidate for preventing atherosclerosis.
목차
등록된 정보가 없습니다.
참고문헌 (41)
참고문헌 신청
[학술지(정기간행물)] - 임선영 / 2004 / 된장 메탄올 추출물의 인체 암세포 성장 억제 효과 및 DNA 합성 저해 효과 / 한국식품영양과학회지 33 (6) : 936 ~ 940
[학술지(정기간행물)] - 임선영 / 2007 / 된장 분획물의 항돌연변이 및 암세포 증식 억제효과와 interleukin-2 생성에 미치는 영향 / 생명과학회지 17 (6) : 791 ~ 797
[학술지(정기간행물)] - Kim MJ / 1990 / Studies on the changes of taste compounds during soy paste fermentation / Korean J Food Cook Sci 6 : 1 ~ 8
[학술지(정기간행물)] - Coward L / 1993 / Genistein, daidzein, and their β-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets / J Agric Food Chem 41 : 1961 ~ 1967
[학술지(정기간행물)] - Hamalainen M / 2007 / Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages / Mediators Inflamm 2007 : 45673 ~
[학술지(정기간행물)] - 임선영 / 2007 / 된장 분획물의 항돌연변이 및 암세포 증식 억제효과와 interleukin-2 생성에 미치는 영향 / 생명과학회지 17 (6) : 791 ~ 797
[학술지(정기간행물)] - Kim MJ / 1990 / Studies on the changes of taste compounds during soy paste fermentation / Korean J Food Cook Sci 6 : 1 ~ 8
[학술지(정기간행물)] - Coward L / 1993 / Genistein, daidzein, and their β-glycoside conjugates: antitumor isoflavones in soybean foods from American and Asian diets / J Agric Food Chem 41 : 1961 ~ 1967
[학술지(정기간행물)] - Hamalainen M / 2007 / Anti-inflammatory effects of flavonoids: genistein, kaempferol, quercetin, and daidzein inhibit STAT-1 and NF-κB activations, whereas flavone, isorhamnetin, naringenin, and pelargonidin inhibit only NF-κB activation along with their inhibitory effect on iNOS expression and NO production in activated macrophages / Mediators Inflamm 2007 : 45673 ~
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Hexane fraction from the ethanolic extract of Sargassum serratifolium suppresses cell adhesion molecules via regulation of NF-κB and Nrf2 pathway in human umbilical vein endothelial cells
Fisheries and Aquatic Sciences
2019 .01
-
혈관내피세포에서 TNF-α로 유도되는 혈관염증에 대한 쏙(Upogebia major) 효소가수분해물의 억제 효과
한국수산과학회지
2018 .04
-
순무(Brassica rapa L.)의 TNF-α 자극에 의해 유도된 혈관염증 개선 효능
한국식품영양과학회지
2020 .02
-
상추 추출물(Lactuca sativa L.)의 혈관내피세포에서 항염증 작용과고지방 식이 생쥐에서 혈중 지질농도 개선에 미치는 영향
한국식품영양학회지
2016 .12
-
대식세포에서 나문재 분말을 함유한 된장의 항염증 효과
한국식품영양학회지
2019 .01
-
Inhibition Effect of Enzymatic Hydrolysate from Japanese Mud Shrimp (Upogebia major) on TNF-α-induced Vascular Inflammation in HUVEC cells
한국수산과학회 양식분과 학술대회
2018 .05
-
Cirsium japonicum var. maackii Extract Suppress Vascular Adhesion Factor Expression in TNF-α-treated Human Vascular Endothelial Cells by Inhibiting NF-κB Activation
한국식품영양과학회 학술대회발표집
2022 .10
-
Protective effects of Angelica keiskei extract against TNF-α-induced oxidative stress and vascular inflammation in human umbilical vein endothelial cells
Food Science and Preservation
2024 .08
-
Ethanolic extract from Sargassum serratifolium inhibits tumor necrosis factor-α-mediated vascular inflammation in human umbilical vein endothelial cells
한국수산과학회 양식분과 학술대회
2015 .10
-
Quality Characteristics of Commercial Doenjang and Traditional Doenjang
한국식품영양과학회 학술대회발표집
2015 .08
-
Angelica keiskei extract suppress VCAM-1 and ICAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation
한국식품영양과학회 학술대회발표집
2023 .10
-
저장기간에 따른 전통된장과 개량식된장의 이화학적 특성, 기능성분 및 대사체 분석
한국식품영양학회지
2016 .10
-
The Effect of Raphanus sativus on Expression of Adhesion Molecules in Human Aortic Endothelial Cells
한국식품영양과학회 학술대회발표집
2015 .08
-
Mass spectrometry-based metabolomic study of traditional Doenjang effects against hepatic fibrosis
Applied Biological Chemistry
2016 .01
-
Analysis of differences in flavor and sensory characteristics of doenjang and Korean -style doenjang
한국식품영양과학회 학술대회발표집
2022 .10
-
SARGAQUINOIC ACID ISOLATED FROM Sargassium serratifolium INHIBITS TUMOR NECROSIS FACTOR-α-MEDIATED VASCULAR INFLAMMATION IN HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS
한국수산과학회 양식분과 학술대회
2015 .05
-
Comparison of organic and non-organic doenjang from physiochemical, antioxidant activities and sensorial perspectives
한국식품영양과학회 학술대회발표집
2021 .10
-
Improvement Effect of Turnip (Brassica rapa L.) on TNF-αinduced vascular inflammation
한국식품영양과학회 학술대회발표집
2019 .10
-
경기지역 전통 된장의 발효 기간 중 온도와 품질 변화
한국식품영양학회지
2020 .01
-
Anti-inflammatory effect of medicinal plants extracts in LPS-induced RAW264.7 cells
한국식품영양과학회 학술대회발표집
2021 .10
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2018-059-003060782