지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제22권 제4호
- 발행연도
- 2019.1
- 수록면
- 369 - 376 (8page)
이용수
초록· 키워드
오류제보하기
Purpose: The aim of this study was to evaluate the clinical significance of inflammatory biomarkers in acute infectious diarrhea among children. Methods: Clinical parameters including fever, bacterial and viral etiology based on stool culture and multiplex polymerase chain reaction, and nine biomarkers including C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and leukocytes in blood and calprotectin, lactoferrin, myeloperoxidase, polymorphonuclear elastase, leukocytes, and occult blood in feces were evaluated in children who were hospitalized due to acute diarrhea without underlying disease. Results: A total of 62 patients were included. Among these patients, 33 had fever, 18 showed bacterial infections, and 40 patients were infected with 43 viruses. Of all the biomarkers, CRP was significantly correlated with fever ( p <0.001). CRP, ESR, calprotectin, lactoferrin, myeloperoxidase, fecal leukocytes, and occult blood were significantly associated with infection with bacterial pathogens ( p <0.001, p =0.04, p =0.03, p =0.003, p =0.02, p =0.03, p =0.002, respectively). The combination of CRP and fecal lactoferrin at their best cut-off values (13.7 mg/L and 22.8 µg/mL, respectively) yielded a sensitivity of 72.2%, and a specificityof 95.5% for bacterial etiology compared with their individual use. Conclusion: Blood CRP is a useful diagnostic marker for both fever and bacterial etiology in acute pediatric diarrhea. The combination of CRP and fecal lactoferrin yields better diagnostic capability for bacterial etiology than their use alone for acute diarrhea in children without underlying gastrointestinal disease.
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등록된 정보가 없습니다.
참고문헌 (20)
참고문헌 신청
Lanata CF / 2013 / Global causes of diarrheal disease mortality in children <5 years of age : a systematic review / PLoS One 8:e72788
GBD 2013 Mortality and Causes of Death Collaborators / 2015 / Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 / Lancet 385:117~171
Thielman NM / 2004 / Clinical practice. Acute infectious diarrhea / N Engl J Med 350:38~47
Shastri YM / 2008 / Prospective multicenter study evaluating fecal calprotectin in adult acute bacterial diarrhea / Am J Med 121:1099~1106
이해미 / 2015 / Clinical Significance of Fecal Lactoferrin and Multiplex Polymerase Chain Reaction in Patients with Acute Diarrhea / Gut and Liver 9(5):636~640
GBD 2013 Mortality and Causes of Death Collaborators / 2015 / Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 / Lancet 385:117~171
Thielman NM / 2004 / Clinical practice. Acute infectious diarrhea / N Engl J Med 350:38~47
Shastri YM / 2008 / Prospective multicenter study evaluating fecal calprotectin in adult acute bacterial diarrhea / Am J Med 121:1099~1106
이해미 / 2015 / Clinical Significance of Fecal Lactoferrin and Multiplex Polymerase Chain Reaction in Patients with Acute Diarrhea / Gut and Liver 9(5):636~640
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