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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 263 - 271 (9page)
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초록· 키워드
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Background: Hyaluronic acid (HA)-based microneedle patch has recently been studied for wrinkle improvement. Cross-linked HA (CLHA) is widely used in dermal fillers. Acetyl hexapeptide-8 (AHP-8) and epidermal growth factor (EGF) are used for cosmetic ingredients. Objective: This study aimed to verify the efficacy of the CLHA/HA-based patch with microstructure (microneedle patch) containing AHP-8 or EGF. Methods: A total of 52 Korean females were enrolled in a double-blind, randomized, controlled, splitface trial. The subjects were divided into 3 groups: (1) microneedle patch alone, (2) microneedle patch/AHP-8, and (3) microneedle patch/EGF. The treatment was applied on the periorbital and nasolabial fold area for 4 hours to completely dissolve the microstructures once per week for 29 days. Evaluations, including photodamage scoring, image analysis with Antera 3DⓇ (Miravex, Ireland), skin hydration measurement, and adverse effect assessments, were performed at each visit. Results: Fifty subjects (96.2%) completed this clinical study. On day 29 after application, statistically significant improvements in wrinkle and skin hydration were observed in all groups (p＜0.01). Treatment with microneedle patch/AHP-8 and microneedle patch/EGF showed statistically significant improvements in wrinkle compared with microneedle patch alone (p＜0.05). No serious adverse effects were noted. Conclusion: Combination of CLHA-based microneedle patch and functional cosmetic ingredients can improve wrinkle with minimal discomfort.
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참고문헌 (31)
참고문헌 신청
Papakonstantinou E / 2012 / Hyaluronic acid : a key molecule in skin aging / Dermatoendocrinol 4:253~258
Prestwich GD / 1998 / Controlled chemical modification of hyaluronic acid : synthesis, applications, and biodegradation of hydrazide derivatives / J Control Release 53:93~103
Bulpitt P / 1999 / New strategy for chemical modification of hyaluronic acid : preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels / J Biomed Mater Res 47:152~169
Al-Sibani M / 2015 / Evaluation of invitro degradation rate of hyaluronic acid-based hydrogel cross-linked with 1, 4-butanediol diglycidyl ether(BDDE)using RP-HPLC and UV-Vis spectroscopy / J Drug Deliv Sci Technol 29:24~30
Kenne L / 2013 / Modification and cross-linking parameters in hyaluronic acid hydrogels--definitions and analytical methods / Carbohydr Polym 91:410~418
Prestwich GD / 1998 / Controlled chemical modification of hyaluronic acid : synthesis, applications, and biodegradation of hydrazide derivatives / J Control Release 53:93~103
Bulpitt P / 1999 / New strategy for chemical modification of hyaluronic acid : preparation of functionalized derivatives and their use in the formation of novel biocompatible hydrogels / J Biomed Mater Res 47:152~169
Al-Sibani M / 2015 / Evaluation of invitro degradation rate of hyaluronic acid-based hydrogel cross-linked with 1, 4-butanediol diglycidyl ether(BDDE)using RP-HPLC and UV-Vis spectroscopy / J Drug Deliv Sci Technol 29:24~30
Kenne L / 2013 / Modification and cross-linking parameters in hyaluronic acid hydrogels--definitions and analytical methods / Carbohydr Polym 91:410~418
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