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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.04
- 수록면
- 109 - 116 (8page)
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초록· 키워드
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Objective : Solar ultraviolet (UV) light can cause photoaging of human skin. Many researchers have focused on effective prevention to mitigate the aging process. This study was aimed to investigate anti-wrinkle effects of pomegranate concentration solution (PCS) using photoaged hairless mouse model.
Method : To clarify the protective effect of PCS against UVB-induced photo-damage, water capacity was measured with transepidermal water loss (TEWL) in SKH-1 hairless mice. In addition, image of skin replicas was analyzed.
Results : Our results showed that the PCS treatment protects skin against UVB-induced photoaging, based on the parameters including moisture capacity and TEWL. According to visual assessment of skin replica, application of 1 ml/kg PCS inhibited UV-induced wrinkle formation in mice skin as compared to the vehicleapplied control mice.
Conclusion : Taken together, these results indicated that PCS could improve skin wrinkle formation induced by UVB irradiation in SHK-1 hairless mice. PCS could be applied as an anti-wrinkle agent
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등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Rittie, L. / 2002 / UV-light-induced signal cascades and skin aging / Ageing Res Rev 1(4):705~720
Cevenini, E / 2008 / Human models of aging and longevity / Expert Opin Biol Ther 8(9):1393~1405
Gilchrest, B. A / 1990 / Skin aging and photoaging / Dermatol Nurs 2(2):79~82
Buechner, N / 2008 / Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1 / Exp Gerontol 43(7):633~637
Honda, A / 2008 / Interleukin-1beta and macrophage migration inhibitory factor(MIF)in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression / J Dermatol Sci 49(1):63~72
Cevenini, E / 2008 / Human models of aging and longevity / Expert Opin Biol Ther 8(9):1393~1405
Gilchrest, B. A / 1990 / Skin aging and photoaging / Dermatol Nurs 2(2):79~82
Buechner, N / 2008 / Changes of MMP-1 and collagen type Ialpha1 by UVA, UVB and IRA are differentially regulated by Trx-1 / Exp Gerontol 43(7):633~637
Honda, A / 2008 / Interleukin-1beta and macrophage migration inhibitory factor(MIF)in dermal fibroblasts mediate UVA-induced matrix metalloproteinase-1 expression / J Dermatol Sci 49(1):63~72
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