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- 2019.1
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Macrophage is an important innate immune cell that not only initiates inflammatory responses, but also functions in tissuerepair and anti-inflammatory responses. Regulating macrophage activity is thus critical to maintain immune homeostasis. Tyro3, Axl, and Mer are integral membrane proteins that constitute TAM family of receptor tyrosine kinases (RTKs). Growing evidence indicates that TAM family receptors play an important role in anti-inflammatory responses through modulating the function of macrophages. First, macrophages can recognize apoptotic bodies through interaction between TAM family receptors expressed on macrophages and their ligands attached to apoptotic bodies. Without TAM signaling, macrophages cannot clear up apoptotic cells, leading to broad inflammation due to over-activation of immune cells. Second, TAM signaling can prevent chronic activation of macrophages by attenuating inflammatory pathways through particular pattern recognition receptors and cytokine receptors. Third, TAM signaling can induce autophagy which is an important mechanism to inhibit NLRP3 inflammasome activation in macrophages. Fourth, TAM signaling can inhibit polarization of M1 macrophages. In this review, we will focus on mechanisms involved in how TAM family of RTKs can modulate function of macrophage associated with antiinflammatory responses described above. We will also discuss several human diseases related to TAM signaling and potential therapeutic strategies of targeting TAM signaling
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참고문헌 (64)
참고문헌 신청
Alciato, F. / 2010 / TNF-alpha, IL-6, and IL-1 expression is inhibited by Gas6 in monocytes/macrophages / J. Leukoc. Biol 87:869~875
Behrens, E. M. / 2003 / The mer receptor tyrosine kinase : expression and function suggest a role in innate immunity / Eur. J. Immunol 33:2160~2167
Ben-Batalla, I. / 2013 / Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma / Blood 122:2443~2452
Caberoy, N. B. / 2012 / Galectin-3 is a new MerTK-specific eat-me signal / J. Cell Physiol 227:401~407
Caberoy, N. B. / 2010 / Tubby and tubby‐like protein 1 are new MerTK ligands for phagocytosis / EMBO J 29:3898~3910
Behrens, E. M. / 2003 / The mer receptor tyrosine kinase : expression and function suggest a role in innate immunity / Eur. J. Immunol 33:2160~2167
Ben-Batalla, I. / 2013 / Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma / Blood 122:2443~2452
Caberoy, N. B. / 2012 / Galectin-3 is a new MerTK-specific eat-me signal / J. Cell Physiol 227:401~407
Caberoy, N. B. / 2010 / Tubby and tubby‐like protein 1 are new MerTK ligands for phagocytosis / EMBO J 29:3898~3910
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