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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 281 - 291 (11page)
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초록· 키워드
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Tissue-resident macrophages play an important role in maintaining tissue homeostasis and innate immune defense against invading microbial pathogens. Brain-resident macrophages can be classified into microglia in the brain parenchyma and non-parenchymal brain macrophages, also known as central nervous system-associated or borderassociated macrophages, in the brain-circulation interface. Microglia and non-parenchymal brain macrophages, including meningeal, perivascular, and choroid plexus macrophages, are mostly produced during embryonic development, and maintained their population by selfrenewal. Microglia have gained much attention for their dual roles in the maintenance of brain homeostasis and the induction of neuroinflammation. In particular, diverse phenotypes of microglia have been increasingly identified under pathological conditions. Single-cell phenotypic analysis revealed that microglia are highly heterogenous and plastic, thus it is difficult to define the status of microglia as M1/M2 or resting/activated state due to complex nature of microglia. Meanwhile, physiological function of non-parenchymal brain macrophages remain to be fully demonstrated. In this review, we have summarized the origin and signatures of brainresident macrophages and discussed the unique features of microglia, particularly, their phenotypic polarization, diversity of subtypes, and inflammasome responses related to neurodegenerative diseases.
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참고문헌 (102)
참고문헌 신청
Ayata, P. / 2018 / Epigenetic regulation of brain region-specific microglia clearance activity / Nat. Neurosci 21:1049~1060
Bain, C. C. / 2014 / Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice / Nat. Immunol 15:929~937
Bar, E. / 2019 / Microglia roles in synaptic plasticity and myelination in homeostatic conditions and neurodevelopmental disorders / Glia 67:2125~2141
Bennett, M. L. / 2016 / New tools for studying microglia in the mouse and human CNS / Proc. Natl. Acad. Sci. U. S. A 113:E1738~E1746
Biber, K. / 2007 / Neuronal 'On'and 'Off' signals control microglia / Trends Neurosci 30:596~602
Bain, C. C. / 2014 / Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice / Nat. Immunol 15:929~937
Bar, E. / 2019 / Microglia roles in synaptic plasticity and myelination in homeostatic conditions and neurodevelopmental disorders / Glia 67:2125~2141
Bennett, M. L. / 2016 / New tools for studying microglia in the mouse and human CNS / Proc. Natl. Acad. Sci. U. S. A 113:E1738~E1746
Biber, K. / 2007 / Neuronal 'On'and 'Off' signals control microglia / Trends Neurosci 30:596~602
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