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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 168 - 171 (4page)
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초록· 키워드
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During the clinical trial development of directly acting antivirals (DAAs), evidence regarding the treatment efficacy in chronic hepatitis C patients with hepatocellular carcinoma (HCC) was scarce because these patients have always been excluded. Apart from the clinical trials, more HCC patients are currently being treated in daily practice, given that these treatments are highly effective and involve well-tolerated regimens. Large scale, real-world studies have demonstrated potentially suboptimal antiviral treatment efficacy in HCC patients who received DAAs. It is postulated that the impairment of the bioavailability of DAAs may account for the inferior treatment response. However, the results could not be generalized across all studies. The differing results were attributed to diverse patient characteristics, suboptimal regimens or imprecise definitions of active cancer statuses at the time of treatment initiation. Additional large-scale studies that utilize the treatment of choice in clearly defined HCC patients with different disease severities are warranted to clarify the issue.
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참고문헌 (19)
참고문헌 신청
Global Burden of Disease Liver Cancer Collaboration / 2017 / The burden of primary liver cancer and underlying etiologies from 1990 to 2015at the global, regional, and national level : results from the global burden of disease study 2015 / JAMA Oncol 3:1683~1691
European Association for the Study of the Liver / 2018 / EASL Clinical Practice Guidelines : management of hepatocellular carcinoma / J Hepatol 69:182~236
Yu ML / 2017 / Time-degenerative factors and the risk of hepatocellular carcinoma after antiviral therapy among hepatitis C virus patients : a model for prioritization of treatment / Clin Cancer Res 23:1690~1697
Ioannou GN / 2017 / HCV eradication induced by directacting antiviral agents reduces the risk of hepatocellular carcinoma / J Hepatol :030
Huang JF / 2011 / The efficacy and safety of pegylated interferon plus ribavirin combination therapy in chronic hepatitis c patients with hepatocellular carcinoma post curative therapies-a multicenter prospective trial / J Hepatol 54:219~226
European Association for the Study of the Liver / 2018 / EASL Clinical Practice Guidelines : management of hepatocellular carcinoma / J Hepatol 69:182~236
Yu ML / 2017 / Time-degenerative factors and the risk of hepatocellular carcinoma after antiviral therapy among hepatitis C virus patients : a model for prioritization of treatment / Clin Cancer Res 23:1690~1697
Ioannou GN / 2017 / HCV eradication induced by directacting antiviral agents reduces the risk of hepatocellular carcinoma / J Hepatol :030
Huang JF / 2011 / The efficacy and safety of pegylated interferon plus ribavirin combination therapy in chronic hepatitis c patients with hepatocellular carcinoma post curative therapies-a multicenter prospective trial / J Hepatol 54:219~226
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