지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 502 - 510 (9page)
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초록· 키워드
오류제보하기
Background: In our preliminary study, we screened for their potential to inhibit 5α-reductase, and Melandrium firmum (MF) extract showed the most potent activity as confirmed by high-performance liquid chromatography (HPLC). Objective: This study aimed to investigate the effects of MF extract on 5 α-reductase activity and its mechanisms of action in the prevention or treatment of androgenetic alopecia. Methods: HPLC was used to measure 5α-reductase activity. The hair growth-promoting effect of MF extract in the shaved dorsal skin of C57BL/6J mice was studied for 30 days. Hair follicles were examined by histological examination. Protein and mRNA levels of growth factors involved in hair growth were determined by western blotting, and reverse transcriptionpolymerase chain reaction (RT-PCR) and qPCR, respectively. Cell proliferation was measured by (3-(4, 5-dimethylthiazol- 2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)- 2H-tetrazolium) assay. Results: MF extract at 0.5 mg/ml showed 43.5% inhibition of 5α-reductase. MF extract promoted hair growth by inducing anagen phase reflected by skin color, hair density, and the number and size of hair follicles. It not only reduces the expression of transforming growth factor-beta 1 (TGF-β1) and Dickkopf-1 (DKK-1), but also markedly upregulated insulin-like growth factor 1 and keratinocyte growth factor in the dorsal dermal tissue. Ursolic acid, ecdcysteron, and ergosterol peroxide were identified as active constituents by activity-guided fractionation to inhibit 5α-reductase. They decreased the gene expression of TGF-β1 and DKK-1 in human hair dermal papilla cells. Conclusion: In summary, these finding indicate that MF extract might be a good drug candidate for hair growth promotion. (
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참고문헌 (26)
참고문헌 신청
Kerscher M / 2007 / Cosmetic dermatology and skin care / Eur J Dermatol 17:180~182
Paik JH / 2001 / The prevalence and types of androgenetic alopecia in Korean men and women / Br J Dermatol 145:95~99
강정일 / 2012 / Hair-Loss Preventing Effect of Grateloupia elliptica / Biomolecules & Therapeutics 20(1):118~124
Ellis JA / 2002 / Androgenetic alopecia : pathogenesis and potential for therapy / Expert Rev Mol Med 4:1~11
Hadshiew IM / 2004 / Burden of hair loss : stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia / J Invest Dermatol 123:455~457
Paik JH / 2001 / The prevalence and types of androgenetic alopecia in Korean men and women / Br J Dermatol 145:95~99
강정일 / 2012 / Hair-Loss Preventing Effect of Grateloupia elliptica / Biomolecules & Therapeutics 20(1):118~124
Ellis JA / 2002 / Androgenetic alopecia : pathogenesis and potential for therapy / Expert Rev Mol Med 4:1~11
Hadshiew IM / 2004 / Burden of hair loss : stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia / J Invest Dermatol 123:455~457
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