지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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Objectives: Astragalus membranaceus has been reported to inhibit immune responses, but its effect on hair loss is not clear. In this study, the effect of A. membranaceus extract (AM) on hair regrowth in C57BL/6 mice with natural hair loss in the telogen phase was investigated.
Methods: Mice with natural hair loss were topically treated with 1% AM on the dorsal skin for 2 weeks. Dorsal skin samples were stained with hematoxylin and eosin and probed with an anti-mouse CD8a IgG. The mRNA expression levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin (IL)-4 were measured by reverse transcription polymerase chain reaction and quantitative real-time polymerase chain reaction.
Results: AM treatment induced hair regrowth in hair loss mice, while control mice suffered continued hair loss. Tapering hair shafts and broken hair follicles were decreased as well as CD8+ T lymphocyte infiltration. In addition, the expressions of TNF-α, IFN-γ and IL-4 were reduced by AM treatment. Also, AM treatment significantly increased the KGF expressions in Hs68 fibroblast cells.
Conclusion: These results suggest that topical application of A. membranaceus may be an alternative therapy for hair loss.
Methods: Mice with natural hair loss were topically treated with 1% AM on the dorsal skin for 2 weeks. Dorsal skin samples were stained with hematoxylin and eosin and probed with an anti-mouse CD8a IgG. The mRNA expression levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ and interleukin (IL)-4 were measured by reverse transcription polymerase chain reaction and quantitative real-time polymerase chain reaction.
Results: AM treatment induced hair regrowth in hair loss mice, while control mice suffered continued hair loss. Tapering hair shafts and broken hair follicles were decreased as well as CD8+ T lymphocyte infiltration. In addition, the expressions of TNF-α, IFN-γ and IL-4 were reduced by AM treatment. Also, AM treatment significantly increased the KGF expressions in Hs68 fibroblast cells.
Conclusion: These results suggest that topical application of A. membranaceus may be an alternative therapy for hair loss.
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References
참고문헌 (64)
참고문헌 신청
Stenn KS / 2001 / Controls of Hair Follicle Cycling / Physiological Reviews 81(1):449~494
Min BG / 2005 / Diagnosis and treatment of hair & scalp disorders / Hanmi Book :21~30
Zoe DD / 1995 / Cosmetics in dermatology, 2nd / Churchill Livingstone :179~191
Ahn SG / 2003 / Common Skin Disease / Pacific publisher :437
Korean Dermatology Association / 2014 / Textbook of Dermatology, 6Th / Med book :551~557
Min BG / 2005 / Diagnosis and treatment of hair & scalp disorders / Hanmi Book :21~30
Zoe DD / 1995 / Cosmetics in dermatology, 2nd / Churchill Livingstone :179~191
Ahn SG / 2003 / Common Skin Disease / Pacific publisher :437
Korean Dermatology Association / 2014 / Textbook of Dermatology, 6Th / Med book :551~557
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