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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 56 - 68 (13page)
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Purpose: To assess the effectiveness of alpha-1 adrenergic receptor blockers (α1-blockers) in the treatment of female lower urinary tract symptoms (LUTS). Methods: A literature search was conducted using the PubMed/MEDLINE, Embase, and Cochrane Library databases. Fourteen studies with 1,319 patients were ultimately included. The study comprised 2 analyses: a comparison of urinary symptom scores, maximal flow rate (Qmax), and postvoid residual (PVR) urine volume before and after α1-blocker administration in 8 prospective, open-label studies and 5 randomized clinical trials (RCTs); and an evaluation of the same variables in α1-blocker and placebo groups in 4 RCTs. Results: The first meta-analysis showed that, following treatment, patients exhibited statistically significant symptom relief (mean difference [MD], -5.85; 95% confidence interval [CI], -7.71 to -3.99; P<0.00001), increased Qmax (MD, 3.67 mL/sec; 95% CI, 2.76–4.59 mL/sec; P<0.00001), and decreased PVR volume (MD, -28.46 mL; 95% CI, -34.99 to -21.93 mL; P<0.00001). In the second meta-analysis, α1-blockers demonstrated significant symptom relief relative to placebo (MD, -1.60; 95% CI, -2.68 to -0.51; P=0.004). However, no significant differences were observed in Qmax (MD, 0.05 mL/sec; 95% CI, -0.74 to 0.83 mL/sec, P=0.91) and PVR (MD, -8.10 mL; 95% CI, -32.32 to 16.12 mL, P=0.51) between the α1-blocker and placebo groups. Conclusions: These analyses suggest that α1-blockers are effective in the treatment of female LUTS patients. However, the effect of α1-blockers on female LUTS should be assessed according to the underlying cause, and the role of α1-blockers in combination therapy with other drugs should also be investigated.
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참고문헌 (35)
참고문헌 신청
Oelke M / 2013 / EAU guidelines on the treatment and follow-up of non-neurogenic male lower urinary tract symptoms including benign prostatic obstruction / Eur Urol 64:118~140
Haylen BT / 2011 / An International Urogynecological Association(IUGA)/International Continence Society(ICS)joint terminology and classification of the complications related directly to the insertion of prostheses(meshes, implants, tapes)and grafts in female pelvic floor surgery / Neurourol Urodyn 30:2~12
Haylen BT / 2007 / Has the true prevalence of voiding difficulty in urogynecology patients been underestimated? / Int Urogynecol J Pelvic Floor Dysfunct 18:53~56
Patel R / 2001 / Bladder outlet obstruction in women : prevalence, recognition, and management / Curr Urol Rep 2:379~387
이영숙 / 2018 / Efficacy of an Alpha-Blocker for the Treatment of Nonneurogenic Voiding Dysfunction in Women: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial / International Neurourology Journal 22(1):30~40
Haylen BT / 2011 / An International Urogynecological Association(IUGA)/International Continence Society(ICS)joint terminology and classification of the complications related directly to the insertion of prostheses(meshes, implants, tapes)and grafts in female pelvic floor surgery / Neurourol Urodyn 30:2~12
Haylen BT / 2007 / Has the true prevalence of voiding difficulty in urogynecology patients been underestimated? / Int Urogynecol J Pelvic Floor Dysfunct 18:53~56
Patel R / 2001 / Bladder outlet obstruction in women : prevalence, recognition, and management / Curr Urol Rep 2:379~387
이영숙 / 2018 / Efficacy of an Alpha-Blocker for the Treatment of Nonneurogenic Voiding Dysfunction in Women: An 8-Week, Randomized, Double-Blind, Placebo-Controlled Trial / International Neurourology Journal 22(1):30~40
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