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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 173 - 179 (7page)
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The aims of this study were to assess the risk of tuberculosis (TB) and the status of latenttuberculosis infection (LTBI) in Korean patients with inflammatory bowel disease (IBD)receiving tumor necrosis factor (TNF)-α blockers. We reviewed medical records of 525Korean IBD patients (365 TNF-α blocker naïve and 160 TNF-α blocker exposed) betweenJanuary 2001 and December 2013. The crude incidence of TB was significantly higher inIBD patients receiving TNF-α blockers compared to TNF-α-blocker-naïve patients (3.1% vs.
0.3%, P = 0.011). The mean incidence of TB per 1,000 patient-years was 1.84 for theoverall IBD population, 4.89 for TNF-α blocker users, and 0.45 for TNF-α-blocker-naïvepatients. The adjusted risk ratio of TB in IBD patients receiving TNF-α blocker was 11.7 (95%confidence interval, 1.36-101.3). Pulmonary TB was prevalent in patients treated withTNF-α blockers (80.0%, 4/5). LTBI was diagnosed in 17 (10.6%) patients, and none of the17 LTBI patients experienced reactivation of TB during treatment with TNF-α blockers.
Treatment with TNF-α blockers significantly increased the risk of TB in IBD patients inKorea. De novo pulmonary TB infection was more prevalent than reactivation of LTBI,suggesting an urgent need for specific recommendations regarding TB monitoring duringTNF-α blocker therapy.
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참고문헌 (28)
참고문헌 신청
Dave M / 2014 / Opportunistic infections due to inflammatory bowel disease therapy / Inflamm Bowel Dis 20:196~212
Keane J / 2005 / TNF-blocking agents and tuberculosis: new drugs illuminate an old topic / Rheumatology 44:714~720
Keane J / 2001 / Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent / N Engl J Med 345:1098~1104
Lee SK / 2013 / Mycobacterial infections in patients treated with tumor necrosis factor antagonists in South Korea / Lung 191:565~571
Ng SC / 2012 / Genetics of inflammatory bowel disease in Asia : systematic review and meta-analysis / Inflamm Bowel Dis 18:1164~1176
Keane J / 2005 / TNF-blocking agents and tuberculosis: new drugs illuminate an old topic / Rheumatology 44:714~720
Keane J / 2001 / Tuberculosis associated with infliximab, a tumor necrosis factor alpha-neutralizing agent / N Engl J Med 345:1098~1104
Lee SK / 2013 / Mycobacterial infections in patients treated with tumor necrosis factor antagonists in South Korea / Lung 191:565~571
Ng SC / 2012 / Genetics of inflammatory bowel disease in Asia : systematic review and meta-analysis / Inflamm Bowel Dis 18:1164~1176
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