지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 283 - 290 (8page)
이용수
초록· 키워드
오류제보하기
A rapid diagnostic test (RDT) kit was developed to detect non-structural protein 1 (NS1) of yellow fever virus (YFV) using monoclonal antibody. NS1 protein was purified from the cultured YFV and used to immunize mice. Monoclonal antibody to NS1 was selected and conjugated with colloidal gold to produce the YFV NS1 RDT kit. The YFV RDTs were evaluated for sensitivity and specificity using positive and negative samples of monkeys from Brazil and negative human blood samples from Korea. Among monoclonal antibodies, clones 3A11 and 3B7 proved most sensitive, and used for YFV RDT kit. Diagnostic accuracy of YFV RDT was fairly high; Sensitivity was 0.0% and specificity was 100% against Dengue viruses type 2 and 3, Zika, Chikungunya and Mayaro viruses. This YFV RDT kit could be employed as a test of choice for point-of-care diagnosis and large scale surveys of YFV infection under clinical or field conditions in endemic areas and on the globe.
목차
Abstract
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (22)
참고문헌 신청
Jentes ES / 2011 / The revised global yellow fever risk map and recommendations for vaccination, 2010 : consensus of the Informal WHO Working Group on Geographic Risk for Yellow Fever / The Lancet Infect Dis 11:622~632
Tomlinson W / 2005 / Centennial year of yellow fever eradication in New Orleans and the United States, 1905–2005 / J La State Med Soc 157:216~217
Kubota RL / 2003 / Sweeping method to scan breeding places for dengue and urban yellow fever vetors / Rev Saude Publica 37:263~265
Gubler D / 2004 / The changing epidemiology of yellow fever and dengue, 1900 to 2003 : full circle / Comp Immunol and Microbiol of Infect Dis 27:319~330
World Health Organization / Yellow fever
Tomlinson W / 2005 / Centennial year of yellow fever eradication in New Orleans and the United States, 1905–2005 / J La State Med Soc 157:216~217
Kubota RL / 2003 / Sweeping method to scan breeding places for dengue and urban yellow fever vetors / Rev Saude Publica 37:263~265
Gubler D / 2004 / The changing epidemiology of yellow fever and dengue, 1900 to 2003 : full circle / Comp Immunol and Microbiol of Infect Dis 27:319~330
World Health Organization / Yellow fever
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UCI(KEPA) : I410-ECN-0101-2020-513-000262882