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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 101 - 110 (10page)
- DOI
- 10.3746/jkfn.2020.49.1.101
이용수
초록· 키워드
오류제보하기
RAW 264.7 cells were used to test if the extracts of water dropwort (Oenanthe javanica), cultivated in either tap water (OJ) or water containing germanium (GO) affect the secretion of nitric oxide and pro-inflammatory cytokines. Normal male ICR mice were administered OJ or GO extracts orally to evaluate the production of nitric oxide/pro-inflammatory cytokines and activities of natural killer (NK) cells in spleen and abdominal cavity. ICP-AES determined the germanium contents of the GO extracts with 116.68 mg germanium being found in 1 kg of the GO extracts. The chemical compositions of the GO extracts were analyzed using LC-Q-orbitrap and chlorogenic acid, neochlorogenic acid, caffeic acid, quercetin, isorhamnetin were detected in the GO extracts. In lipopolysaccharide-stimulated RAW 264.7 cells, the levels of nitric oxide and pro-inflammatory cytokines were decreased by treatments with the OJ and GO extracts, but the interferon-gamma (IFN-γ) levels were increased. The nitric oxide levels were reduced by both OJ and GO extracts in the spleen of normal male ICR mice fed 400 mg/kg of OJ or GO extracts. The levels of pro-inflammatory cytokines were also decreased by both OJ and GO extracts, but the IFN-γ levels were increased. Both OJ and GO extracts elevated the additional NK cell activities in the spleen and abdominal cavity. Overall, these results provide evidence that GO extracts are better than OJ extracts in terms of inhibiting the inflammatory responses. Therefore, GO extracts may be used as novel and natural functional food source to produce anti-inflammatory foods.
목차
ABSTRACT
서론
재료 및 방법
결과 및 고찰
요약
REFERENCES
참고문헌 (37)
참고문헌 신청
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Clark BD, Bedrosian I, Schindler R, Cominelli F, Cannon JG, Shaw AR, et al. Detection of interleukin 1α and 1β in rabbit tissues during endotoxemia using sensitive radioimmunoassays. J Appl Physiol. 1991. 71:2412-2418.
Ferrandez MD, Correa R, Del Rio M, De la Fuente M. Effects in vitro of several antioxidants on the natural killer function of aging mice. Exp Gerontol. 1999. 34:675-685.
Ghatak SB, Panchal SJ. Investigation of the immunomodulatory potential of oryzanol isolated from crude rice bran oil in experimental animal models. Phytother Res. 2012. 26:1701-1708.
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UCI(KEPA) : I410-ECN-0101-2020-594-000344008