지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.12
- 수록면
- 104 - 114 (11page)
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초록· 키워드
오류제보하기
Sjögren"s syndrome (SS) is a chronic heterogeneous disease that mainly affects exocrine glands, leading to sicca syndromes such as xerostomia. Despite the second highest prevalence rate among systemic autoimmune diseases, its pathophysiology remains largely unknown. Here we report that SKG mice, a cardinal model of Th17 cell-mediated arthritis, also develop a secondary form of SS-like disorder upon systemic exposure to purified curdlan, a type of β-glucan. The reduced production of saliva was not caused by focal immune cell infiltrates but was associated with IgG deposits in salivary glands. Sera from curdlaninjected SKG mice contained elevated titers of IgG (predominantly IgG₁), autoantibody to the muscarinic type 3 receptor (M3R) and inhibited carbachol-induced Ca<SUP>2+</SUP> signaling in salivary acinar cells. These results suggest that the Th17 cells that are elicited in SKG mice promote the production of salivary gland-specific autoantibodies including anti-M3R IgG; the antibodies are then deposited on acinar cells and inhibit M3R-mediated signaling required for salivation, finally leading to hypofunction of the salivary glands. This type II hypersensitivity reaction may explain the origin of secondary SS occurring without focal leukocyte infiltrates.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (29)
참고문헌 신청
Sandhya P / 2017 / Update on pathogenesis of Sjögren's syndrome / Curr Rheumatol Rev 13:5~22
Maślińska M / 2015 / Sjögren's syndrome: still not fully understood disease / Rheumatol Int 35:233~241
박성환 / 2019 / Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren's Syndrome / Immune Network 19(4):1~13
Sharma R / 2019 / Sjögren syndrome without focal lymphocytic infiltration of the salivary glands / J Rheumatol
Ramos-Casals M / 2007 / The overlap of Sjögren's syndrome with other systemic autoimmune diseases / Semin Arthritis Rheum 36:246~255
Maślińska M / 2015 / Sjögren's syndrome: still not fully understood disease / Rheumatol Int 35:233~241
박성환 / 2019 / Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate Disease Activity and Glandular Inflammation in Patients with Primary Sjögren's Syndrome / Immune Network 19(4):1~13
Sharma R / 2019 / Sjögren syndrome without focal lymphocytic infiltration of the salivary glands / J Rheumatol
Ramos-Casals M / 2007 / The overlap of Sjögren's syndrome with other systemic autoimmune diseases / Semin Arthritis Rheum 36:246~255
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UCI(KEPA) : I410-ECN-0101-2020-517-000376054