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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Tuberculosis (TB) remains a major health problem worldwide. TB depends not only on the characteristics of the Mycobacterium tuberculosis (MTB) but also on the genetic susceptibility of infected patients. Recent studies have suggested that FOXO3 play an important role in the human immune associated disorder, such as TB. It was previously reported that FOXO3 genetic variants associated with a risk of TB in Chinese population. In this study, we confirm whether the genetic polymorphism of the FOXO3 gene, which was previously in Chinese, is reproduced in Korean population. Of the 154 SNPs were extracted from the FOXO3 gene, reproducibility analysis of the four SNPs performed in the previous study showed that there was a statistically significant correlation in the three SNPs (rs4946935, rs1536057, rs3800228). This study suggests that polymorphism of the FOXO3 gene in Koreans may affect the onset of tuberculosis and could be used to treat and prevent tuberculosis.
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참고문헌 (21)
참고문헌 신청
Arden KC / 2008 / FOXO animal models reveal a variety of diverse roles for FOXO transcription factors / Oncogene 27:2345~2350
Bouzeyen R / 2019 / FOXO3 transcription factor regulates IL-10 expression in Mycobacteria-infected macrophages, tuning their polarization and the subsequent adaptive immune response / Frontiers in Immunology 10:2922
Brunet A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor / Cell 96:857~868
Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nature Genetics 41:527~534
Comstock GW / 1978 / Tuberculosis in twins : a re-analysis of the Prophit survey / The American Review of Respiratory Disease 117:621~624
Bouzeyen R / 2019 / FOXO3 transcription factor regulates IL-10 expression in Mycobacteria-infected macrophages, tuning their polarization and the subsequent adaptive immune response / Frontiers in Immunology 10:2922
Brunet A / 1999 / Akt promotes cell survival by phosphorylating and inhibiting a forkhead transcription factor / Cell 96:857~868
Cho YS / 2009 / A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits / Nature Genetics 41:527~534
Comstock GW / 1978 / Tuberculosis in twins : a re-analysis of the Prophit survey / The American Review of Respiratory Disease 117:621~624
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UCI(KEPA) : I410-ECN-0101-2020-510-000511923