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논문 기본 정보

자료유형
학술저널
저자정보
김태경 (서울대학교)
저널정보
한국체육과학회 한국체육과학회지 한국체육과학회지 제29권 제2호 (자연과학 편)
발행연도
2020.4
수록면
1,089 - 1,098 (10page)
DOI
10.35159/kjss.2020.04.29.2.1089

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초록· 키워드

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OBJECTIVES: The purpose of this study was to investigate the effects of wheel exercise on neurogenesis progression in depression mice model.
MATERNAL/METHODS: The experimental mice were 10 weeks, except those that showed lower 20% exercise after 5 days of pre-training. Forced exercise program was run for 1 hour at a speed of 9m/min. In neurogenesis, to confirm that wheel exercise differs from a one-time stimulus response, random sampling classified the control (n=8), the experimental group-1 (6 day + 20min, n=8), and the experimental group-2 (6 day + 60min, n=8). To c ompare a ccording to the p eriod of wheel e x ercise, random sampling classified the control (n=14), t he e x perimental g roup-1 ( 14 d ay, n=12), and the experimental group-2 (21 day, n=12). Depression mice model were treated for 14 days of restraint stress 2 hours per day. In order to confirm the changes of neuronal cell proliferation and differentiation by wheel exercise treatment in the depression model, random sampling classified the control (n=8), stress (n=8), stress + imipramine (21days after stress, 20㎎/㎏, n=8), stress + exercise (21days after stress, n=6).
RESULTS: Short-term exercise stimulation of 20 minutes and 60 minutes after continuous wheel exercise does not affect neurogenesis. Ki67 and DCX positive cells increased with the duration of wheel exercise, and 21 day wheel exercise treatment in depression mice showed an increase neurogenesis such as antidepressant.
CONCLUSION: These results suggest that continuous wheel exercise is an important nonpharmacologic approach to long-term neuronal production by increasing the proliferation and differentiation of reduced neurogenesis due to depression.

목차

Abstract
Ⅰ. 서론
Ⅱ. 연구방법
Ⅲ. 결과
Ⅳ. 논의
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