지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.6
- 수록면
- 79 - 87 (9page)
이용수
초록· 키워드
오류제보하기
Major depressive disorder is a highly prevalent psychiatric condition that causes serious health concern and psychosocial consequences. Nevertheless, about one third of the patients with major depressive disorder have treatmentresistant depression (i.e., a failure to respond to two or more antidepressant drugs). In addition, it takes at least two weeks to several months before the antidepressants have an effect. In the field of emergency psychiatry, this time lag has always been a serious obstacle in the treatment of suicidal patients. Since 2000, the ketamine has emerged as a novel therapeutic agent for major depressive disorder and suicidality with rapid onset and robust response rates. In 2019, the U.S. Food and Drug Administration (U.S. FDA) approved the S-enantiomer of ketamine, esketamine as a drug for treatment-resistant depression. However, the U.S. FDA approved it with a Risk Evaluation and Mitigation Strategy (REMS) to mitigate the risk of serious adverse effects resulting from sedation, dissociation, cardiovascular instability, and potential abuse. Although we still do not have enough experience about the efficacy and safety of this new medication, the interests of clinicians and patients are rapidly growing. In this narrative review, the pharmacological characteristics, the mechanism of action, the psychiatric effects and side effects, and a consensus statement on the use of ketamine were provided.
목차
서론
본론
결론
참고문헌
참고문헌 (47)
참고문헌 신청
Hong JP / 2017 / 2016 The Survey of Mental Disorders in Korea
Greenberg PE / 2015 / The economic burden of adults with major depressive disorder in the United States(2005 and 2010) / J Clin Psychiatry 76:155~162
Walker ER / 2015 / Mortality in mental disorders and global disease burden implications : a systematic review and meta-analysis / JAMA Psychiatry 72:334~341
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps : a STAR*D report / Am J Psychiatry 163:1905~1917
Hantouche E / 2010 / Explained factors of suicide attempts in major depression / J Affect Disord 127:305~308
Greenberg PE / 2015 / The economic burden of adults with major depressive disorder in the United States(2005 and 2010) / J Clin Psychiatry 76:155~162
Walker ER / 2015 / Mortality in mental disorders and global disease burden implications : a systematic review and meta-analysis / JAMA Psychiatry 72:334~341
Rush AJ / 2006 / Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps : a STAR*D report / Am J Psychiatry 163:1905~1917
Hantouche E / 2010 / Explained factors of suicide attempts in major depression / J Affect Disord 127:305~308
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NLRP1-Mediated Antidepressant Effect of Ketamine in Chronic Unpredictable Mild Stress Model in Rats
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Effects of ketamine on the severity of depression and anxiety following postoperative mechanical ventilation: a single-blind randomized clinical trial in Iran
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UCI(KEPA) : I410-ECN-0101-2020-512-000659415