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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 283 - 291 (9page)
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초록· 키워드
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Objective NOD-like receptor protein 1 (NLRP1) inflammasome complex has been recently associated with chronic unpredictable mild stress (CUMS) model of depression. Our aim was to investigate whether ketamine-induced antidepressant effect is associated with suppression of NLRP1. Methods Wistar albino rats were divided into control, CUMS, CUMS+acute ketamine (a single 10 mg/kg dose) and CUMS+chronic ketamine (daily 10 mg/kg injections for 3 weeks) groups (n=10 for each group). Sucrose preference test and forced swimming test were performed to assess anhedonia and immobility time respectively for the severety of depression symptoms. Brain tissues were dissected and prefrontal cortex and hippocampus regions were used for real-time polymerase chain reaction (PCR) and immunohistochemical analysis. Results CUMS procedure significantly induced depressive-like symptoms whereas both acute and chronic ketamine treatment ameliorated them. mRNA expression levels of NLRP1, caspase 1, apoptosis-associated speck-like protein containing a CARD (ASC), NF-κB, endothelial nitric oxide synthase, IL-1β, IL-6, toll-like receptor 4 (TLR-4) and purinergic 2×7 receptor (P2X7R) and numbers of Iba- 1+and GFAP+glial cells were reduced by acute and/or chronic ketamine treatment. Conclusion In the present study for the first time upstream and downstream elements of the NLRP1 inflammasome complex are shown to be suppressed by ketamine thus reinforcing the involvement of NLRP1 in the physiopathology of depression.
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참고문헌 (48)
참고문헌 신청
Iwata M / 2013 / The inflammasome : pathways linking psychological stress, depression, and systemic illnesses / Brain Behav Immun 31:105~114
Palazidou E / 2012 / The neurobiology of depression / Br Med Bull 101:127~145
Sanacora G / 2012 / Towards a glutamate hypothesis of depression : an emerging frontier of neuropsychopharmacology for mood disorders / Neuropharmacology 62:63~77
Browne CA / 2013 / Antidepressant effects of ketamine : mechanisms underlying fast-acting novel antidepressants / Front Pharmacol 4:161
Zarate C / 2013 / New paradigms for treatment-resistant depression / Ann N Y Acad Sci 1292:21~31
Palazidou E / 2012 / The neurobiology of depression / Br Med Bull 101:127~145
Sanacora G / 2012 / Towards a glutamate hypothesis of depression : an emerging frontier of neuropsychopharmacology for mood disorders / Neuropharmacology 62:63~77
Browne CA / 2013 / Antidepressant effects of ketamine : mechanisms underlying fast-acting novel antidepressants / Front Pharmacol 4:161
Zarate C / 2013 / New paradigms for treatment-resistant depression / Ann N Y Acad Sci 1292:21~31
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