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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.4
- 수록면
- 69 - 86 (18page)
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초록· 키워드
오류제보하기
An excessive hyperinflammatory response-caused septic shock is a major medical problem that is associated with pathogenic bacterial infections leading to high mortality rates. The intestinal microbiota and the associated elaborated metabolites such as short chain fatty acid butyrate have been shown to relieve pathogenic bacterial-caused acute inflammation. Butyrate can down-regulate inflammation by inhibiting the growth of pathobionts, increasing mucosal barrier integrity, encouraging obligate anaerobic bacterial dominance and decreasing oxygen availability in the gut. Butyrate can also decrease excessive inflammation through modulation of immune cells such as increasing functionalities of M2 macrophages and regulatory T cells and inhibiting infiltration by neutrophils. Therefore, various approaches can be used to increase butyrate to relieve pathogenic bacterial-caused hyperinflammation. In this review we summarize the roles of butyrate in attenuating pathogenic bacterial-caused hyperinflammatory responses and discuss the associated plausible mechanisms.
목차
ABSTRACT
INTRODUCTION
INHIBITORY EFFECT OF BUTYRATE ON PATHOGENIC BACTERIAL INFECTION
INHIBITION OF INFLAMMATION BY BUTYRATE
STRATEGIES TO ENRICH BUTYRATE IN THE INTESTINES AS AN ADJUNCT THERAPY
CONCLUSIONS
REFERENCES
참고문헌 (112)
참고문헌 신청
Lappin E / 2009 / Gram-positive toxic shock syndromes / Lancet Infect Dis 9:281~290
Hotchkiss RS / 2013 / Sepsis-induced immunosuppression : from cellular dysfunctions to immunotherapy / Nat Rev Immunol 13:862~874
Hotchkiss RS / 2016 / Sepsis and septic shock / Nat Rev Dis Primers 2:16045
Wei Y / 2016 / Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis / Crit Care 20:332
Nagpal R / 2017 / Bacterial translocation from the gut to the distant organs : an overview / Ann Nutr Metab 71(Suppl 1):11~16
Hotchkiss RS / 2013 / Sepsis-induced immunosuppression : from cellular dysfunctions to immunotherapy / Nat Rev Immunol 13:862~874
Hotchkiss RS / 2016 / Sepsis and septic shock / Nat Rev Dis Primers 2:16045
Wei Y / 2016 / Successful treatment with fecal microbiota transplantation in patients with multiple organ dysfunction syndrome and diarrhea following severe sepsis / Crit Care 20:332
Nagpal R / 2017 / Bacterial translocation from the gut to the distant organs : an overview / Ann Nutr Metab 71(Suppl 1):11~16
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자가면역반응에 의한 구강점막질환
박준상
대한치과의사협회지
1994
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구강내 면역계에 대한 기본 고찰
김성민
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UCI(KEPA) : I410-ECN-0101-2020-517-000894440